Basic studies in antimicrobial PDT

Photodynamic therapy in veterinary medicine: from basics to clinical practice

dc.contributorSELLERA, FABIO P.
dc.contributorNASCIMENTO, CRISTIANE L.
dc.contributorRIBEIRO, MARTHA S.
dc.creatorNASCIMENTO, CRISTIANE L.
dc.creatorSELLERA, FABIO P.
dc.creatorRIBEIRO, MARTHA S.
dc.date2016
dc.date2018-03-06T18:11:29Z
dc.date2018-03-06T18:11:29Z
dc.date.accessioned2023-09-28T14:06:41Z
dc.date.available2023-09-28T14:06:41Z
dc.identifierhttp://repositorio.ipen.br/handle/123456789/28664
dc.identifier10.1007/978-3-319-45007-0_11
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8998912
dc.descriptionMicroorganisms (MO) multiply rapidly and mutations that guarantee its survival forward to antimicrobials become prevalent in new populations. The inexorable rise of multidrug-resistant MO leads to an effort to search for alternative approaches that, hypothetically, MO could not easily develop resistance. Antimicrobial photodynamic therapy (PDT) is an effective alternative treatment for infected lesions in animals. The goal of the technique is to destroy a sufficient number of pathogenic MO to prevent recolonization and avoid unacceptable destruction of the host tissue. An important observation concerns the selectivity of the photosensitizer by microbial cells when compared to the host. This is because the photosensitizer (PS) uptake by host cells is slower than by MO. If the site of infection is irradiated after a short interval from the PS application (minutes), the damage to host tissue is minimized. Currently, antimicrobial PDT has proven its effectiveness against bacteria, virus, fungi, and parasites. This chapter reviews the literature regarding antimicrobial PDT especially for veterinary medicine.
dc.format157-168
dc.publisherSpringer
dc.rightsopenAccess
dc.subjectantimicrobial agents
dc.subjectmethylene blue
dc.subjectcattle
dc.subjectskin diseases
dc.subjectinfectious diseases
dc.titleBasic studies in antimicrobial PDT
dc.titlePhotodynamic therapy in veterinary medicine: from basics to clinical practice
dc.typeCap??tulo de livro
dc.coverageI
dc.localGewerbestrasse, Switzerland


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