The effect of texturing Al2O3 and Al2O3/ZrO2 surfaces using fem- 7 tosecond laser has been evaluated in terms of the roughness, wettability and 8 microstructure of the substrate to increase growth efficiency and adhesion of 9 hydroxyapatite. Femtosecond laser treatment of these materials causes phase 10 transformation from alpha-alumina to gamma-alumina. Heat effects during fem- 11 tosecond laser treatment causes the grains to be in the nanometer scale. Without 12 heat effects, the grains are in the micrometer scale. The use of femtosecond laser 13 permits control of the surface roughness of the alumina specimens. The higher the 14 femtosecond laser energy, the higher is the wettability of the specimen and the total 15 surface energy. Specimens with laser textured surfaces upon immersion in 1.5 SBF 16 for 6 and 15 days revealed apatite layers well bonded to the substrate and without 17 detachment. The adhesion of apatite to surfaces of specimens that were not textured 18 with femtosecond laser was inadequate