Nanostructured materials based on mesoporous silica and mesoporous silica/apatite as osteogenic growth peptide carriers

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMendes, L. S.
dc.creatorSaska, S.
dc.creatorMartines, M. A U
dc.creatorMarchetto, Reinaldo
dc.date2014-05-27T11:30:47Z
dc.date2016-10-25T18:54:39Z
dc.date2014-05-27T11:30:47Z
dc.date2016-10-25T18:54:39Z
dc.date2013-10-01
dc.date.accessioned2017-04-06T02:40:40Z
dc.date.available2017-04-06T02:40:40Z
dc.identifierMaterials Science and Engineering C, v. 33, n. 7, p. 4427-4434, 2013.
dc.identifier0928-4931
dc.identifierhttp://hdl.handle.net/11449/76727
dc.identifierhttp://acervodigital.unesp.br/handle/11449/76727
dc.identifier10.1016/j.msec.2013.06.040
dc.identifierWOS:000325445700112
dc.identifier2-s2.0-84881186388
dc.identifierhttp://dx.doi.org/10.1016/j.msec.2013.06.040
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/897417
dc.descriptionThe aim of this work was the preparation of inorganic mesoporous materials from silica, calcium phosphate and a nonionic surfactant and to evaluate the incorporation and release of different concentrations of osteogenic growth peptide (OGP) for application in bone regeneration. The adsorption and release of the labeled peptide with 5,6-carboxyfluorescein (OGP-CF) from the mesoporous matrix was monitored by fluorescence spectroscopy. The specific surface area was 880 and 484 m2 g- 1 for pure silica (SiO) and silica/apatite (SiCaP), respectively; the area influenced the percentage of incorporation of the peptide. The release of OGP-CF from the materials in simulated body fluid (SBF) was dependent on the composition of the particles, the amount of incorporated peptide and the degradation of the material. The release of 50% of the peptide content occurred at around 4 and 30 h for SiCaP and SiO, respectively. In conclusion, the materials based on SiO and SiCaP showed in vitro bioactivity and degradation; thus, these materials should be considered as alternative biomaterials for bone regeneration. © 2013 Elsevier B.V.
dc.languageeng
dc.relationMaterials Science and Engineering C
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectControlled release
dc.subjectMesoporous silica
dc.subjectOsteogenic growth peptide
dc.subjectBone regeneration
dc.subjectDegradation of the material
dc.subjectIn-vitro bioactivity
dc.subjectMesoporous matrix
dc.subjectMesoporous Silica
dc.subjectOsteogenic growth peptides
dc.subjectSimulated body fluids
dc.subjectBiological materials
dc.subjectBiomaterials
dc.subjectFluorescence spectroscopy
dc.subjectMesoporous materials
dc.subjectNonionic surfactants
dc.subjectSilica
dc.subjectPeptides
dc.titleNanostructured materials based on mesoporous silica and mesoporous silica/apatite as osteogenic growth peptide carriers
dc.typeOtro


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