An approach to local immunotoxicity induced by adjuvanted vaccines

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBatista-Duharte, Alexander
dc.creatorPortuondo, Deivys
dc.creatorCarlos, Iracilda Zeppone
dc.creatorPérez, Oliver
dc.date2014-05-27T11:30:45Z
dc.date2016-10-25T18:54:29Z
dc.date2014-05-27T11:30:45Z
dc.date2016-10-25T18:54:29Z
dc.date2013-09-27
dc.date.accessioned2017-04-06T02:39:57Z
dc.date.available2017-04-06T02:39:57Z
dc.identifierInternational Immunopharmacology, v. 17, n. 3, p. 526-536, 2013.
dc.identifier1567-5769
dc.identifier1878-1705
dc.identifierhttp://hdl.handle.net/11449/76651
dc.identifierhttp://acervodigital.unesp.br/handle/11449/76651
dc.identifier10.1016/j.intimp.2013.07.025
dc.identifierWOS:000327280100007
dc.identifier2-s2.0-84884519475
dc.identifierhttp://dx.doi.org/10.1016/j.intimp.2013.07.025
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/897343
dc.descriptionThe occurrence of injection site reactions following immunization is the most frequently reported toxicity manifestation of vaccines; however, the different types of local reactions and the different mechanisms involved are still unclear. Here, the current advances in adjuvants and the role that adjuvants play in local reactions are reviewed. The role of adjuvants in the formation of the loco-regional complex (LRC), which consists of the injection site, draining lymphatic vessels and regional lymph nodes, is also discussed. Finally, strategies and recommendations for the rational design of adjuvanted vaccines are discussed, with a particular interest in the reduction of local inflammation. © 2013 Elsevier B.V.
dc.languageeng
dc.relationInternational Immunopharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAction mechanism
dc.subjectAdjuvant
dc.subjectImmunotoxicity
dc.subjectLocal reaction
dc.subjectVaccine
dc.subjectBCG vaccine
dc.subjectpoliomyelitis vaccine
dc.subjectvaccine
dc.subjectadaptive immunity
dc.subjectantigen presenting cell
dc.subjectArthus phenomenon
dc.subjectBCG vaccination
dc.subjectcarcinogenesis
dc.subjectdelayed hypersensitivity
dc.subjectdrug induced disease
dc.subjectgranuloma
dc.subjecthuman
dc.subjectimmunization
dc.subjectimmunotoxicity
dc.subjectinjection site nodule
dc.subjectinnate immunity
dc.subjectlymphadenitis
dc.subjectlymphatic drainage
dc.subjectlymphoid hyperplasia
dc.subjectPersian Gulf syndrome
dc.subjectpriority journal
dc.subjectpseudolymphoma
dc.subjectsubcutaneous nodule
dc.subjecttuberculosis
dc.subjecturticaria
dc.titleAn approach to local immunotoxicity induced by adjuvanted vaccines
dc.typeOtro


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