Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGomes, Felipe V.
dc.creatorAlves, Fernando H.F.
dc.creatorGuimarães, Francisco S.
dc.creatorCorrea, Fernando M.A.
dc.creatorResstel, Leonardo B.M.
dc.creatorCrestani, Carlos Cesar
dc.date2014-05-27T11:30:32Z
dc.date2016-10-25T18:53:08Z
dc.date2014-05-27T11:30:32Z
dc.date2016-10-25T18:53:08Z
dc.date2013-09-01
dc.date.accessioned2017-04-06T02:36:47Z
dc.date.available2017-04-06T02:36:47Z
dc.identifierEuropean Neuropsychopharmacology, v. 23, n. 9, p. 1096-1104, 2013.
dc.identifier0924-977X
dc.identifier1873-7862
dc.identifierhttp://hdl.handle.net/11449/76401
dc.identifierhttp://acervodigital.unesp.br/handle/11449/76401
dc.identifier10.1016/j.euroneuro.2012.09.007
dc.identifierWOS:000325739000013
dc.identifier2-s2.0-84884208568
dc.identifierhttp://dx.doi.org/10.1016/j.euroneuro.2012.09.007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/897101
dc.descriptionSystemic administration of cannabidiol (CBD) is able to attenuate cardiovascular responses to acute restraint stress through activation of 5-HT1A receptors. Previous results from our group suggest that the bed nucleus of the stria terminalis (BNST) is involved in the antiaversive effects of the CBD. Moreover, it has been proposed that synapses within the BNST influence restraint-evoked cardiovascular changes, in particular by an inhibitory influence on the tachycardiac response associated to restraint stress. Thus, the present work investigated the effects of CBD injected into the BNST on cardiovascular changes induced by acute restraint stress and if these effects would involve the local activation of 5-HT1A receptors. The exposition to restraint stress increased both blood pressure and heart rate (HR). The microinjection of CBD (30 and 60nmol) into the BNST enhanced the restraint-evoked HR increase, in a dose-dependent manner, without affecting the pressor response. The selective 5-HT1A receptor antagonist WAY100635 by itself did not change the cardiovascular responses to restraint stress, but blocked the effects of CBD. These results showed that CBD microinjected into the BNST enhanced the HR increase associated with acute restraint stress without affecting the blood pressure response. Although these results are not in agreement with those observed after systemic administration of CBD, they are similar to effects observed after reversible inactivation of the BNST. Moreover, similar to the effects observed after systemic administration, CBD effects in the BNST seem to depend on activation of 5-HT1A receptors. © 2012 Elsevier B.V. and ECNP.
dc.languageeng
dc.relationEuropean Neuropsychopharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectArterial pressure
dc.subjectAversive situation and serotonin receptors
dc.subjectCannabinoids
dc.subjectExtended amygdala
dc.subjectHeart rate
dc.subjectantibiotic agent
dc.subjectbromethol
dc.subjectcannabidiol
dc.subjectflunixin meglumine
dc.subjectn [2 [4 (2 methoxyphenyl) 1 piperazinyl]ethyl] n (2 pyridyl)cyclohexanecarboxamide
dc.subjectpentabiotico
dc.subjectserotonin 1A antagonist
dc.subjectserotonin 1A receptor
dc.subjectunclassified drug
dc.subjectamygdaloid nucleus
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarterial pressure
dc.subjectblood pressure
dc.subjectcardiovascular response
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectheart rate
dc.subjectimmobilization stress
dc.subjectmale
dc.subjectmicroinjection
dc.subjectnonhuman
dc.subjectpressor response
dc.subjectpriority journal
dc.subjectrat
dc.subjectstria terminalis
dc.titleCannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor
dc.typeOtro


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