Organotins: A review of their reproductive toxicity, biochemistry, and environmental fate

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGraceli, Jones Bernardes
dc.creatorSena, Gabriela Cavati
dc.creatorLopes, Pedro Francisco Iguatemy
dc.creatorZamprogno, Gabriela Carvalho
dc.creatorda Costa, Mércia Barcellos
dc.creatorGodoi, Ana Flavia Locateli
dc.creatordos Santos, Dayana Moscardi
dc.creatorMarchi, Mary Rosa Rodrigues de
dc.creatordos Santos Fernandez, Marcos Antonio
dc.date2014-05-27T11:28:45Z
dc.date2016-10-25T18:46:03Z
dc.date2014-05-27T11:28:45Z
dc.date2016-10-25T18:46:03Z
dc.date2013-04-01
dc.date.accessioned2017-04-06T02:18:15Z
dc.date.available2017-04-06T02:18:15Z
dc.identifierReproductive Toxicology, v. 36, p. 40-52.
dc.identifier0890-6238
dc.identifier1873-1708
dc.identifierhttp://hdl.handle.net/11449/74942
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74942
dc.identifier10.1016/j.reprotox.2012.11.008
dc.identifierWOS:000316307000007
dc.identifier2-s2.0-84871914112
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2012.11.008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895701
dc.descriptionThe review purposes are to (1) evaluate the experimental evidence for adverse effects on reproduction and metabolism and (2) identify the current knowledge of analytical procedures, biochemistry and environmental aspects relating to organotins. Organotins are pollutants that are used as biocides in antifouling paints. They produce endocrine-disrupting effects in mollusks, such as imposex. In rodents, organotin exposure induces developmental and reproductive toxicity as well as alteration of metabolic homeostasis through its action as an obesogen. The adverse effects that appear in rodents have raised concerns about organotins' potential health risk to humans in relation to organotin exposure. At present, triorganotin, such as tributyltin, have been demonstrated to produce imposex, and mammalian reproductive and metabolic toxicity. For most mammals, triorganotin exposure predominantly occurs through the ingestion, and this compound can cross the placenta. With these risks in mind, it is important to improve our knowledge of organotins' effects on environmental health. © 2012 Elsevier Inc.
dc.languageeng
dc.relationReproductive Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiochemistry
dc.subjectEnvironmental fate
dc.subjectObesogens
dc.subjectOrganotins
dc.subjectReproductive toxicity
dc.subjectorganotin compound
dc.subjecttributyltin
dc.subjecttriorganotin derivative
dc.subjecttriphenyltin
dc.subjectunclassified drug
dc.subjectanalytic method
dc.subjectbioaccumulation
dc.subjectbiochemistry
dc.subjectchemical analysis
dc.subjectchemical composition
dc.subjectchemical modification
dc.subjectdevelopmental toxicity
dc.subjectendocrine disease
dc.subjectenvironmental aspects and related phenomena
dc.subjectfemale genital system
dc.subjectgonad
dc.subjecthealth hazard
dc.subjecthuman
dc.subjectimmunotoxicity
dc.subjectimpotence
dc.subjectmale genital system
dc.subjectmetabolic disorder
dc.subjectnonhuman
dc.subjectobesity
dc.subjectreproductive toxicity
dc.subjectAnimals
dc.subjectDisinfectants
dc.subjectEndocrine Disruptors
dc.subjectEndocrine System
dc.subjectEnergy Metabolism
dc.subjectEnvironmental Exposure
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunotoxins
dc.subjectInfertility, Female
dc.subjectInfertility, Male
dc.subjectMale
dc.subjectObesity
dc.subjectOrganotin Compounds
dc.subjectTrialkyltin Compounds
dc.subjectMammalia
dc.subjectMollusca
dc.subjectRodentia
dc.titleOrganotins: A review of their reproductive toxicity, biochemistry, and environmental fate
dc.typeOtro


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