Thermal behavior of some antihistamines

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPerpétuo, G. L.
dc.creatorGálico, D. A.
dc.creatorFugita, R. A.
dc.creatorCastro, R. A E
dc.creatorEusébio, M. E S
dc.creatorTreu-Filho, O.
dc.creatorSilva, A. C M
dc.creatorBannach, Gilbert
dc.date2014-05-27T11:28:33Z
dc.date2016-10-25T18:44:52Z
dc.date2014-05-27T11:28:33Z
dc.date2016-10-25T18:44:52Z
dc.date2013-03-01
dc.date.accessioned2017-04-06T02:14:47Z
dc.date.available2017-04-06T02:14:47Z
dc.identifierJournal of Thermal Analysis and Calorimetry, v. 111, n. 3, p. 2019-2028, 2013.
dc.identifier1388-6150
dc.identifierhttp://hdl.handle.net/11449/74643
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74643
dc.identifier10.1007/s10973-012-2247-0
dc.identifierWOS:000315298800048
dc.identifier2-s2.0-84881475988
dc.identifierhttp://dx.doi.org/10.1007/s10973-012-2247-0
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895404
dc.descriptionThermogravimetry (TG), differential scanning calorimetry (DSC), polarized light thermal microscopy (PLTM), as well as X-ray powder diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR) were used to study the thermal behavior and the chemical structure of cimetidine, famotidine, ranitidine-HCl, and nizatidine. The TG-DSC curves show that the famotidine and ranitidine-HCl suffer decomposition during melting and they are thermally less stable in comparison with cimetidine and nizatidine, the latter being the most stable of all the drugs studied in this study. The DSC curves of famotidine and ranitidine-HCl show exothermic peaks immediately after the melting, confirming the occurrence of thermal decomposition. The DSC curves also show that the cimetidine and nizatidine have some thermal stability after melting. The thermal events shown in the PLTM images are consistent with the results shown in the TG-DSC and DSC curves. The XRD patterns show that the cimetidine and famotidine are less crystalline compared with ranitidine-HCl and nizatidine. The theoretical FTIR bands are in agreement with those obtained experimentally, and in some cases, no difference is observed between the theoretical and experimental values, even being identical in one of the cases. © 2012 Akadémiai Kiadó, Budapest, Hungary.
dc.languageeng
dc.relationJournal of Thermal Analysis and Calorimetry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntihistamines
dc.subjectCimetidine
dc.subjectFamotidine
dc.subjectNizatidine
dc.subjectRanitidine
dc.subjectThermal behavior
dc.subjectThermal behaviors
dc.subjectDifferential scanning calorimetry
dc.subjectInfrared spectroscopy
dc.subjectThermogravimetric analysis
dc.subjectX ray powder diffraction
dc.subjectMelting
dc.titleThermal behavior of some antihistamines
dc.typeOtro


Este ítem pertenece a la siguiente institución