Kinetic parameters for thermal decomposition of supramolecular polymers derived from diclofenac-meglumine supramolecular adducts

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCassimiro, Douglas L.
dc.creatorFerreira, Leonardo M.B.
dc.creatorCapela, Jorge M.V.
dc.creatorCrespi, Marisa Spirandeli
dc.creatorRibeiro, Clovis Augusto
dc.date2014-05-27T11:28:13Z
dc.date2016-10-25T18:42:53Z
dc.date2014-05-27T11:28:13Z
dc.date2016-10-25T18:42:53Z
dc.date2013-01-25
dc.date.accessioned2017-04-06T02:10:47Z
dc.date.available2017-04-06T02:10:47Z
dc.identifierJournal of Pharmaceutical and Biomedical Analysis, v. 73, p. 24-28.
dc.identifier0731-7085
dc.identifier1873-264X
dc.identifierhttp://hdl.handle.net/11449/74421
dc.identifierhttp://acervodigital.unesp.br/handle/11449/74421
dc.identifier10.1016/j.jpba.2012.04.019
dc.identifierWOS:000311771100005
dc.identifier2-s2.0-84869505869
dc.identifier0000-0002-7984-5908
dc.identifierhttp://dx.doi.org/10.1016/j.jpba.2012.04.019
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895187
dc.descriptionMeglumine is an aminocarbohydrate able to form supramolecular adducts with organic acids. The recognition is based on hydrogen bonds and the structures resulting from the complexation have high solubility in water. This property has been exploited by the pharmaceutical industry in the improvement of existing drugs, and the successful example of this approach involves the poorly soluble non-steroidal anti-inflammatory drugs (NSAIDs). Investigation of the thermal behavior of adduct obtained from meglumine and the NSAID diclofenac revealed that a polymer-like material is formed from the self-assembly of diclofenac-meglumine adducts in the melt. This polymer showed a high molecular weight around 2.0×105kDa. The kinetic parameters for the thermal decomposition step of the polymer were determined by the Capela-Ribeiro non-linear isoconversional method. From data for the TG curves in nitrogen atmosphere and heating rates of 5, 10, 15 and 20°Cmin-1, the Eα and Bα terms could be determined, and consequently the pre-exponential factor, Aα, as well as the kinetic model, g(α). © 2012 Elsevier B.V.
dc.languageeng
dc.relationJournal of Pharmaceutical and Biomedical Analysis
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdducts
dc.subjectDiclofenac-meglumine
dc.subjectNon-isothermal kinetics
dc.subjectSupramolecular polymers
dc.subjectThermal decomposition
dc.subjectdiclofenac
dc.subjectmeglumine
dc.subjectpolymer
dc.subjectaqueous solution
dc.subjectcomplex formation
dc.subjectcrystallization
dc.subjectdrug decomposition
dc.subjectdrug industry
dc.subjectdrug solubility
dc.subjectdrug structure
dc.subjectglass transition temperature
dc.subjecthydrogen bond
dc.subjectmolecular dynamics
dc.subjectmolecular size
dc.subjectmolecular weight
dc.subjectnonlinear system
dc.subjectpolymerization
dc.subjectpriority journal
dc.subjectproton nuclear magnetic resonance
dc.subjectthermal analysis
dc.titleKinetic parameters for thermal decomposition of supramolecular polymers derived from diclofenac-meglumine supramolecular adducts
dc.typeOtro


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