Artigo
Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat
Autor
Carvalho, Gisele Queiroz
Pereira, Patricia Feliciano
Serrano, Hiara Miguel Stancioli
Franceschini, Sylvia do Carmo Castro
Priore, Silvia Eloiza
Paula, Sérgio Oliveira de
Peluzio, Maria do Carmo Gouveia
Institución
Resumen
The objective of this study was to evaluate the peripheral expression of inflammatory markers in adolescents with different nutritional status and its correlation with parameters of the metabolic syndrome. Seventy-two female postpubescent adolescents were divided into 3 groups: eutrophic (Co), eutrophic with a high body fat percentage (HBF), and overweight (OW). Data related to the parameters of the metabolic syndrome and the peripheral expression of tumour necrosis factor (TNF)-[alpha], interleukin (IL)-6, and IL-10 were evaluated. Higher values of glycemia and insulin resistance were found in the HBF group than in the Co group. No differences related to the peripheral expression of the cytokines were found among the groups. In the HBF group, a positive correlation was observed between TNF-[alpha] and IL-6, IL-10 and the proinflammatory cytokines, and IL-6 and glycemia. In the OW group, a positive correlation was found between IL-6 and triglycerides. Adolescents with normal weight but body fat excess present a metabolic profile and body composition similar to those of overweight adolescents. This suggests that these adolescents have a risk of developing cardiovascular diseases similar to that of overweight adolescents. The positive correlation between IL-10 and TNF-[alpha] and IL-6 suggests an attempt to inhibit the production of these cytokines by IL-10. Cette etude se propose devaluer l'expression peripherique des marqueurs de l'inflammation chez des adolescents de statut nutritionnel different et sa correlation avec le syndrome metabolique. On repartit 72 adolescentes postpubertaires dans trois groupes : eutrophique (Co), eutrophique avec un fort pourcentage de gras (HBF) et en surpoids (OW). On evalue les variables en lien avec le syndrome metabolique et l'expression peripherique de TNF-[alpha], IL-6 et IL-10. Comparativement au groupe Co, le groupe HBF presente des valeurs de glycemie et d'insulinoresistance superieures. On n'observe aucune difference entre les groupes en qui concerne l'expression peripherique des cytokines. Chez le groupe HBF, on observe des correlations positives entre TNF-[alpha] et IL-6, entre IL-10 et les cytokines pro-inflammatoires et entre IL-6 et la glyceemie. Chez le groupe OW, on observe une correlation positive entre IL-6 et les triglycerides. Les adolescentes de poids normal avec un surplus de gras corporel et les adolescentes en surpoids presentent un profil metabolique et une composition corporelle similaires. D'apres ces observations, ces deux groupes d'adolescentes risquent de developper les memes maladies cardiovasculaires. La correlation positive observee entre IL-10 et TNF-[alpha] et IL-6 suggere que les IL-10 tentent d'inhiber la production des cytokines.