Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRamalli Jr, Edvaldo Luiz
dc.creatorBraga, Leonardo Henrique
dc.creatorEvora, Patricia Martinez
dc.creatorAlbuquerque, Agnes Afrodite Sumarelli
dc.creatorCelotto, Andrea Carla
dc.creatorMota, André Lupp
dc.creatorEvora, Paulo Roberto Barbosa
dc.date2014-05-27T11:25:56Z
dc.date2016-10-25T18:34:09Z
dc.date2014-05-27T11:25:56Z
dc.date2016-10-25T18:34:09Z
dc.date2011-07-01
dc.date.accessioned2017-04-06T01:51:16Z
dc.date.available2017-04-06T01:51:16Z
dc.identifierBrazilian Journal of Cardiovascular Surgery, v. 26, n. 3, p. 440-446, 2011.
dc.identifier0102-7638
dc.identifier1678-9741
dc.identifierhttp://hdl.handle.net/11449/72538
dc.identifierhttp://acervodigital.unesp.br/handle/11449/72538
dc.identifier10.5935/1678-9741.20110020
dc.identifier2-s2.0-81355133336.pdf
dc.identifier2-s2.0-81355133336
dc.identifierhttp://dx.doi.org/10.5935/1678-9741.20110020
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/893395
dc.descriptionSeveral studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridges.
dc.languageeng
dc.languagepor
dc.relationBrazilian Journal of Cardiovascular Surgery
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCoronary circulation
dc.subjectEndothelium
dc.subjectMyocardial bridging
dc.subjectACE protein, human
dc.subjectdipeptidyl carboxypeptidase
dc.subjectendothelin 1
dc.subjectadipose tissue
dc.subjectcoronary artery blood flow
dc.subjectcoronary artery disease
dc.subjectcoronary blood vessel
dc.subjecthistology
dc.subjecthuman
dc.subjectmetabolism
dc.subjectmyocardial bridging
dc.subjectparacrine signaling
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectprenatal development
dc.subjectreview
dc.subjectvascular endothelium
dc.subjectAdipose Tissue
dc.subjectCoronary Artery Disease
dc.subjectCoronary Circulation
dc.subjectCoronary Vessels
dc.subjectEndothelin-1
dc.subjectEndothelium, Vascular
dc.subjectHumans
dc.subjectMyocardial Bridging
dc.subjectParacrine Communication
dc.subjectPeptidyl-Dipeptidase A
dc.titleAusência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
dc.typeOtro


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