Lichen metabolites modulate hydrogen peroxide and nitric oxide in mouse macrophages

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCarlos, Iracilda Zeppone
dc.creatorQuilles, Marcela B.
dc.creatorCarli, Camila B. A.
dc.creatorMaia, Danielle C. G.
dc.creatorBenzatti, Fernanda P.
dc.creatorLopes, Thiago I. B.
dc.creatorGianini, Aline S.
dc.creatorBrum, Rosenei L.
dc.creatorVilegas, Wagner
dc.creatordos Santos, Lourdes C.
dc.creatorHonda, Neli K.
dc.date2014-05-27T11:24:02Z
dc.date2016-10-25T18:27:39Z
dc.date2014-05-27T11:24:02Z
dc.date2016-10-25T18:27:39Z
dc.date2009-11-20
dc.date.accessioned2017-04-06T01:37:58Z
dc.date.available2017-04-06T01:37:58Z
dc.identifierZeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 64, n. 9-10, p. 664-672, 2009.
dc.identifier0939-5075
dc.identifierhttp://hdl.handle.net/11449/71247
dc.identifierhttp://acervodigital.unesp.br/handle/11449/71247
dc.identifierWOS:000272764800010
dc.identifier2-s2.0-70449556478.pdf
dc.identifier2-s2.0-70449556478
dc.identifierhttp://www.znaturforsch.com/ac/v64c/c64c.htm
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/892252
dc.descriptionThe activities of perlatolic acid (1), atranorin (2), and lecanoric acid (3) and their derivatives, such as orsellinates and β-methyl orsellinates obtained by alcoholysis, were assessed for stimulation of the release of hydrogen peroxide and nitric oxide in cultures of peritoneal macrophage cells from mice. The hydrogen peroxide production was estimated by oxidation of phenol red, while the Griess reagent was used to determine the nitric oxide production. 1 and 4-methoxy-ethyl orsellinate (XVII) were the compounds that induced the greatest release of H 2O 2, whereas n-pentyl orsellinate (IV), iso-propyl orsellinate (V), sec-butyl orsellinate (VI), and XVII induced a small release of NO. These results indicate that lichen products and their derivatives have potential immune-modulating activities. © 2009 Verlag der Zeitschrift für Naturforschung, Tübingen.
dc.languageeng
dc.relationZeitschrift fur Naturforschung - Section C Journal of Biosciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHydrogen peroxide
dc.subjectLichens
dc.subjectNitric oxide
dc.subjecthydrogen peroxide
dc.subjectnitric oxide
dc.subjectplant extract
dc.subjectanimal
dc.subjectlichens
dc.subjectmacrophage
dc.subjectmetabolism
dc.subjectmouse
dc.subjectAnimals
dc.subjectHydrogen Peroxide
dc.subjectMacrophages
dc.subjectMice
dc.subjectNitric Oxide
dc.subjectPlant Extracts
dc.subjectMus
dc.titleLichen metabolites modulate hydrogen peroxide and nitric oxide in mouse macrophages
dc.typeOtro


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