Effect of remifentanil hydrochloride administered via constant rate infusion on the minimum alveolar concentration of isoflurane in cats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFerreira, Tatiana H.
dc.creatorAguiar, Antonio J. A.
dc.creatorValverde, Alexander
dc.creatorTeixeira Neto, Francisco José
dc.creatorSteagall, Paulo V. M.
dc.creatorSoares, João H. N.
dc.date2014-05-27T11:23:54Z
dc.date2016-10-25T18:27:00Z
dc.date2014-05-27T11:23:54Z
dc.date2016-10-25T18:27:00Z
dc.date2009-05-01
dc.date.accessioned2017-04-06T01:35:59Z
dc.date.available2017-04-06T01:35:59Z
dc.identifierAmerican Journal of Veterinary Research, v. 70, n. 5, p. 581-588, 2009.
dc.identifier0002-9645
dc.identifierhttp://hdl.handle.net/11449/70995
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70995
dc.identifier10.2460/ajvr.70.5.581
dc.identifier2-s2.0-65749108484
dc.identifierhttp://dx.doi.org/10.2460/ajvr.70.5.581
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/892044
dc.descriptionObjective - To evaluate the effects of increasing doses of remifentanil hydrochloride administered via constant rate infusion (CRI) on the minimum alveolar concentration (MAC) of isoflurane in cats. Animals - 6 healthy adult cats. Procedures - For each cat, 2 experiments were performed (2-week interval). On each study day, anesthesia was induced and maintained with isoflurane; a catheter was placed in a cephalic vein for the administration of lactated Ringer's solution or remifentanil CRIs, and a catheter was placed in the jugular vein for collection of blood samples for blood gas analyses. On the first study day, individual basal MAC (MAC Basal) was determined for each cat. On the second study day, 3 remifentanil CRIs (0.25, 0.5, and 1.0 μg/kg/min) were administered (in ascending order); for each infusion, at least 30 minutes elapsed before determination of MAC (designated as MAC R0.25, MAC R0.5, and MAC R1.0, respectively). A 15-minute washout period was allowed between CRIs. A control MAC (MAC Control) was determined after the last remifentanil infusion. Results - Mean ± SD MAC Basal and MAC Control values at sea level did not differ significantly (1.66 ± 0.08% and 1.52 ± 0.21%, respectively). The MAC values determined for each remifentanil CRI did not differ significantly. However, MAC R0.25, MAC R0.5, and MAC R1.0, were significantly decreased, compared with MAC Basal, by 23.4 ± 79%, 29.8 ± 8.3%, and 26.0 ± 9.4%, respectively. Conclusions and Clinical Relevance - The 3 doses of remifentanil administered via CRI resulted in a similar degree of isoflurane MAC reduction in adult cats, indicating that a ceiling effect was achieved following administration of the lowest dose.
dc.languageeng
dc.relationAmerican Journal of Veterinary Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectisoflurane
dc.subjectremifentanil
dc.subjectRinger lactate solution
dc.subjectanesthesia induction
dc.subjectanesthesiological techniques
dc.subjectanimal experiment
dc.subjectblood gas analysis
dc.subjectblood sampling
dc.subjectbreathing rate
dc.subjectcat
dc.subjectcephalic vein
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug dose increase
dc.subjectfemale
dc.subjectheart rate
dc.subjectjugular vein
dc.subjectmale
dc.subjectminimum lung alveolus concentration
dc.subjectnonhuman
dc.subjectsystolic blood pressure
dc.subjectvein catheterization
dc.subjectAnesthetics, Intravenous
dc.subjectAnimals
dc.subjectBlood Gas Analysis
dc.subjectCats
dc.subjectFemale
dc.subjectInfusions, Intravenous
dc.subjectIsoflurane
dc.subjectMale
dc.subjectPiperidines
dc.subjectPulmonary Alveoli
dc.subjectAnimalia
dc.titleEffect of remifentanil hydrochloride administered via constant rate infusion on the minimum alveolar concentration of isoflurane in cats
dc.typeOtro


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