Positive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virus

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBotosso, Viviane F.
dc.creatorZanotto, Paolo M. de A.
dc.creatorUeda, Mirthes
dc.creatorArruda, Eurico
dc.creatorGilio, Alfredo E.
dc.creatorIeira, Sandra E.
dc.creatorStewien, Klaus E.
dc.creatorPeret, Teresa C. T.
dc.creatorJamal, Leda F.
dc.creatorPardini, Maria I. de M. C.
dc.creatorPinho, Joãr
dc.creatorMassad, Duardo
dc.creatorSant'Anna, Osvaldo A.
dc.creatorHolmes, Eddie C.
dc.creatorDurigon, Edison L.
dc.creatorComone, Priscila
dc.creatorDo Sacramento, Patrícia R.
dc.creatorDurigan, Mariana S.
dc.creatorOliveira, Danielle B. L.
dc.creatorMoraes, Claudia T. P.
dc.creatorCampo, Angélica C. A.
dc.creatorLeal, Andréia L.
dc.creatorSilva, Tereza S.
dc.creatorCarvalho, Ariane C. L.
dc.creatorTenório, Elisabeth C. N.
dc.creatorCintra, Otavio A. L.
dc.creatorAnsarah-Sobrinho, Camilo
dc.creatorProençna-Modena, José L.
dc.creatorIwamoto, Marisa A.
dc.creatorDe Paula, Flávia E.
dc.creatorSouza, Maria C. O.
dc.creatorVaz-de-Lima, Lourdes R. A.
dc.creatorMatsumoto, Tokiko K.
dc.creatorSato, Neuza N.
dc.creatorSalgado, Maristela M.
dc.creatorHong, Marisa A.
dc.creatorRequejo, Henry I.
dc.creatorBarbosa, Maria L.
dc.creatorOliveiveira, Carmem A. F.
dc.creatorPassos, Saulo D.
dc.creatorPecchini, Rogério
dc.creatorBerezin, Eitan
dc.creatorSchvartsman, Claudio
dc.creatorPannuti, Cláudio S.
dc.creatorCandeias, João M. G.
dc.creatorHan, Sang W.
dc.creatorGarcia, José F.
dc.creatorCarrilho, Flair J.
dc.creatorFigueiredo, Luíz T. M.
dc.creatorDuarte, Alberto J. Da S.
dc.creatorWolff, José L. C.
dc.creatorRahal, Paula
dc.creatorRichtzenhain, Leonardo J.
dc.creatorGonçales Jr., Fernando L.
dc.creatorDe Lima, Edimo G.
dc.date2014-05-27T11:23:50Z
dc.date2016-10-25T18:26:45Z
dc.date2014-05-27T11:23:50Z
dc.date2016-10-25T18:26:45Z
dc.date2009-01-01
dc.date.accessioned2017-04-06T01:35:08Z
dc.date.available2017-04-06T01:35:08Z
dc.identifierPLoS Pathogens, v. 5, n. 1, 2009.
dc.identifier1553-7366
dc.identifier1553-7374
dc.identifierhttp://hdl.handle.net/11449/70883
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70883
dc.identifier10.1371/journal.ppat.1000254
dc.identifier2-s2.0-59249085256.pdf
dc.identifier2-s2.0-59249085256
dc.identifier0000-0003-1515-702X
dc.identifierhttp://dx.doi.org/10.1371/journal.ppat.1000254
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891948
dc.descriptionHuman respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple lineages of the HRSVA and HRSVB serotypes co-circulate within a single outbreak and display a strongly temporal pattern of genetic variation, with a replacement of dominant genotypes occurring during consecutive years. In the present study we utilized phylogenetic methods to detect and map sites subject to adaptive evolution in the G protein of HRSVA and HRSVB. A total of 29 and 23 amino acid sites were found to be putatively positively selected in HRSVA and HRSVB, respectively. Several of these sites defined genotypes and lineages within genotypes in both groups, and correlated well with epitopes previously described in group A. Remarkably, 18 of these positively selected tended to revert in time to a previous codon state, producing a flipflop phylogenetic pattern. Such frequent evolutionary reversals in HRSV are indicative of a combination of frequent positive selection, reflecting the changing immune status of the human population, and a limited repertoire of functionally viable amino acids at specific amino acid sites.
dc.languageeng
dc.relationPLoS Pathogens
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectepitope
dc.subjectguanine nucleotide binding protein
dc.subjectvirus protein
dc.subjectamino acid substitution
dc.subjectchild
dc.subjectcodon
dc.subjectcontrolled study
dc.subjectgene sequence
dc.subjectgenotype
dc.subjecthuman
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectphylogeny
dc.subjectpreschool child
dc.subjectRespiratory syncytial pneumovirus
dc.subjectrespiratory syncytial pneumovirus a
dc.subjectrespiratory syncytial pneumovirus b
dc.subjectunindexed sequence
dc.subjectvirus gene
dc.subjectgenetic variability
dc.subjectgenetics
dc.subjectmolecular evolution
dc.subjectrespiratory tract infection
dc.subjectHuman respiratory syncytial virus
dc.subjectHydrangea ringspot virus
dc.subjectAmino Acid Substitution
dc.subjectEpitopes
dc.subjectEvolution, Molecular
dc.subjectGenetic Variation
dc.subjectGenotype
dc.subjectGTP-Binding Proteins
dc.subjectHumans
dc.subjectPhylogeny
dc.subjectRespiratory Syncytial Viruses
dc.subjectRespiratory Tract Infections
dc.subjectViral Proteins
dc.titlePositive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virus
dc.typeOtro


Este ítem pertenece a la siguiente institución