Polyethylene gel in the subcutaneous tissue of rats: Histopathologic and systemic evaluation

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSchellini, Silvana Artioli
dc.creatorZimmermann, Gislaine P. M.
dc.creatorHoyama, Erika
dc.creatorPellizzon, Claudia Helena
dc.creatorPadovani, Carlos Roberto
dc.creatorSelva, Dinesh
dc.date2014-05-27T11:23:32Z
dc.date2016-10-25T18:25:26Z
dc.date2014-05-27T11:23:32Z
dc.date2016-10-25T18:25:26Z
dc.date2008-05-01
dc.date.accessioned2017-04-06T01:30:41Z
dc.date.available2017-04-06T01:30:41Z
dc.identifierOrbit, v. 27, n. 3, p. 153-156, 2008.
dc.identifier0167-6830
dc.identifier1744-5108
dc.identifierhttp://hdl.handle.net/11449/70393
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70393
dc.identifier10.1080/01676830701555246
dc.identifier2-s2.0-45749134259
dc.identifierhttp://dx.doi.org/10.1080/01676830701555246
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891499
dc.descriptionPurpose: To evaluate the histological and systemic response to subcutaneous injection of polyethylene gel in rats. Methods: Twenty-one white male rats were divided into 3 groups (G): G1 and G2 received subcutaneous polyethylene gel injection in the dorsal midline and were sacrificed at 30 and 60 postoperative days, respectively. G3 was not exposed to the polyethylene gel and was sacrificed after 60 days. Blood levels of lactate dehydrogenase (LDH), creatine kinase (CK), and alkaline phosphatase (ALP) were evaluated. The heart, kidney, liver, adrenal gland, injection site, and adjacent tissues were histologically examined. The results were submitted to statistical analysis. Results: There was no clinical evidence of extrusion, reduction of the injected volume, or abnormalities in the adjacent tissues. Blood levels of CK and LDH were normal and similar in all groups. ALP levels were significantly lower in G2 than in G1 and G3. The systemic organs were normal on histological examination in the 3 groups evaluated. Microscopically, the polyethylene gel was surrounded by a thin pseudocapsule formation and minimal inflammatory cell response, which decreased from G1 to G2. Conclusion: The subcutaneous injection of polyethylene gel in rats elicited minimal local inflammatory response and no systemic side effects. Copyright © 2008 Informa Healthcare USA, Inc.
dc.languageeng
dc.relationOrbit
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHistology
dc.subjectPolyethylene
dc.subjectRats
dc.subjectSubcutaneous injections
dc.subjectToxicity
dc.subjectalkaline phosphatase
dc.subjectbiomaterial
dc.subjectcreatine kinase
dc.subjectfiller
dc.subjectlactate dehydrogenase
dc.subjectpolyethylene
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectgel
dc.subjecthistopathology
dc.subjectinflammation
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectstatistical analysis
dc.subjectsubcutaneous tissue
dc.subjectsystemic disease
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBiopsy, Needle
dc.subjectDisease Models, Animal
dc.subjectGels
dc.subjectImmunohistochemistry
dc.subjectInjections, Subcutaneous
dc.subjectMale
dc.subjectProstheses and Implants
dc.subjectRandom Allocation
dc.subjectRats, Wistar
dc.subjectReference Values
dc.subjectSensitivity and Specificity
dc.subjectSkin Absorption
dc.subjectSubcutaneous Tissue
dc.titlePolyethylene gel in the subcutaneous tissue of rats: Histopathologic and systemic evaluation
dc.typeOtro


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