dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDomingues, Andréa
dc.date2014-05-27T11:22:00Z
dc.date2016-10-25T18:22:49Z
dc.date2014-05-27T11:22:00Z
dc.date2016-10-25T18:22:49Z
dc.date2006-10-05
dc.date.accessioned2017-04-06T01:20:56Z
dc.date.available2017-04-06T01:20:56Z
dc.identifierJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 3, p. 521-, 2006.
dc.identifier1678-9199
dc.identifierhttp://hdl.handle.net/11449/69164
dc.identifierhttp://acervodigital.unesp.br/handle/11449/69164
dc.identifier10.1590/S1678-91992006000300014
dc.identifierS1678-91992006000300014
dc.identifier2-s2.0-33749171090.pdf
dc.identifier2-s2.0-33749171090
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992006000300014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/890437
dc.descriptionMultiresistant Staphylococcus aureus constitutes an important public health problem, especially in view of its possible spread in nosocomial environments. In the present work, we analyzed the susceptibility profile of 80 S. aureus stains from human infections resistant to at least 10 drugs. For this study, the techniques used were the disk method and minimum inhibitory concentration (MIC) of the following drugs: cefuroxime, ciprofloxacin, clindamycin, erythromycin, gentamycin, imipenem, oxacillin, rifampicin, tetracycline and vancomycin, according the criteria of the National Committee for Clinical Laboratory Standards (NCCLS). Methicillin was included in the antibiogram as a marker, which is usually used in drugs selection for the treatment of staphylococcal infections. Results indicated that the most effective drug was vancomycin. For the other 10 drugs, the percentage of resistant strains ranged from 85% to 93.75%. In relation to the MICs, it was observed that vancomycin (MIC 90% = 0.615ug/ml) was the most effective drug; followed by rifampicin (MIC 90% = 2.6ug/ml) and ciprofloxacin (MIC 90% = 26.6ug/ml). The drugs that showed the least effective activity were cefuroxime, clindamycin, erythromycin, gentamycin, and oxacillin. On the other hand, observation of β-lactamase production revealed that most of the methicillin-resistant strains produced β-lactamase (83.7%), potentiating the risks of nosocomial infections. In general, vancomycin still continues to be one of the most effective drugs for staphylococcal infections therapy.
dc.languageeng
dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDrugs
dc.subjectHuman infections
dc.subjectMethicillin
dc.subjectStaphylococcus aureus
dc.subjectmethicillin resistant Staphylococcus aureus
dc.subjectStaphylococcus
dc.titleEvaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections
dc.typeOtro


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