Inibidores da HIV-integrase: Potencial abordagem farmacológica para tratamento da AIDS
Quimica Nova, v. 29, n. 3, p. 555-562, 2006.
De Melo, Eduardo Borges
Bruni, Aline Thaís
Castro Ferreira, Márcia Miguel
AIDS has the HIV as its etiological agent. Researches has been done to find new pharmacological agents to be used in therapy, because of problems of resistance and side effects. The HIV-integrase inhibitors are some of those new agents that are being studied. This updating focusses on the fundamental information about HIV and HIV-integrase and the main methods being used to develop these new drugs, with examples for each case.