Familial malignant osteopetrosis in children: A case report

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGomes, Monica Fernandes
dc.creatorRangel, Daniela Coelho
dc.creatorStarling, Cláudia Cristina Morais
dc.creatorGoulart, Maria Das Graças Vilela
dc.date2014-05-27T11:21:51Z
dc.date2016-10-25T18:22:09Z
dc.date2014-05-27T11:21:51Z
dc.date2016-10-25T18:22:09Z
dc.date2006-05-01
dc.date.accessioned2017-04-06T01:18:33Z
dc.date.available2017-04-06T01:18:33Z
dc.identifierSpecial Care in Dentistry, v. 26, n. 3, p. 106-110, 2006.
dc.identifier0275-1879
dc.identifierhttp://hdl.handle.net/11449/68866
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68866
dc.identifier10.1111/j.1754-4505.2006.tb01432.x
dc.identifier2-s2.0-33745769707
dc.identifierhttp://dx.doi.org/10.1111/j.1754-4505.2006.tb01432.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/890178
dc.descriptionThe clinical, radiological, pathological and laboratory findings of two brothers with autosomal recessive malignant osteopetrosis are presented. Our findings are similar to characteristics previously reported in the literature about patients with osteopetrosis. The 6-year-old male patient was pale and had petechiae on his arms and legs. He also had macrocephalia, splenomegaly, severe pancytopenia, genu valgus, hypocalcemia, amaurosis, cessation of physical development, generalized bone sclerosis and recurrent infections with a history of multiple incidences of acute otitis media. Generalized bone sclerosis and irregular sclerosis of the maxilla and mandible were seen on radiographs. The oral mucosa was apparently normal but permanent tooth eruption was delayed although there was early loss of deciduous teeth. The recommended treatment was blood transfusion and therapy with antibiotics when necessary; a bone marrow transplant was not possible due to lack of a compatible donor.
dc.languageeng
dc.relationSpecial Care in Dentistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBone disease
dc.subjectHistological and radiological finding
dc.subjectMalignant infantile osteopetrosis
dc.subjectOral manifestation
dc.subjectAlbers Schoenberg disease
dc.subjectcase report
dc.subjectchild
dc.subjectcraniofacial malformation
dc.subjectface asymmetry
dc.subjectfatality
dc.subjectgenetics
dc.subjecthuman
dc.subjectjaw disease
dc.subjectmale
dc.subjectpreschool child
dc.subjectpurpura
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCraniofacial Abnormalities
dc.subjectFacial Asymmetry
dc.subjectFatal Outcome
dc.subjectHumans
dc.subjectMale
dc.subjectMandibular Diseases
dc.subjectMaxillary Diseases
dc.subjectOsteopetrosis
dc.subjectPurpura
dc.titleFamilial malignant osteopetrosis in children: A case report
dc.typeOtro


Este ítem pertenece a la siguiente institución