Plantas do cerrado brasileiro com atividade contra Mycobacterium fortuitum

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorArantes, V. P.
dc.creatorSato, D. N.
dc.creatorVilegas, Wagner
dc.creatorSantos, L. C.
dc.creatorLeite, Clarice Queico Fujimura
dc.date2014-05-27T11:21:45Z
dc.date2016-10-25T18:21:38Z
dc.date2014-05-27T11:21:45Z
dc.date2016-10-25T18:21:38Z
dc.date2005-12-01
dc.date.accessioned2017-04-06T01:16:36Z
dc.date.available2017-04-06T01:16:36Z
dc.identifierRevista de Ciencias Farmaceuticas Basica e Aplicada, v. 26, n. 3, p. 195-198, 2005.
dc.identifier1808-4532
dc.identifier2179-443X
dc.identifierhttp://hdl.handle.net/11449/68635
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68635
dc.identifier2-s2.0-33845549521.pdf
dc.identifier2-s2.0-33845549521
dc.identifierhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/422
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889960
dc.descriptionMycobacterium fortuitum is a rapidly-growing species of bacteria, ubiquitous in the environment and related to important human mycobacterioses. It has been isolated from blood, abscesses, the endocardium and surgical and traumatic wounds. This mycobacterium is hard to treat, being recognized in the literature as resistant even to the drugs used in the treatment of tuberculosis. The objective of this study was to screen extracts prepared from plants of the Brazilian cerrado (extended savanna-like belt) with known activity against M. fortuitum, employing the Microplate Alamar Blue Assay (MABA) as the analytical method. Out of 26 extracts tested against M. fortuitum, the nonpolar extract of Quassia amara (in methylene dichloride) gave the best result (MIC 62.5μg/ mL), followed by the nonpolar extracts of Syngonanthus macrolepsis, Davilla elliptica and Turnera ulmifolia, with equal MICs of 125μg/ml. The polar extracts (in ethanol and methanol) obtained from the same plants were considered inactive, since the MIC values determined were above 500μg/mL and not significantly different from those of extracts from other plants, without known activity.
dc.descriptionMycobacterium fortuitum é uma micobactéria de crescimento rápido, ubíquo na natureza e relacionada a micobacteriose de importância médica. Ela tem sido isolada de bacteremias, abscessos, endocardites, feridas cirúrgicas e traumáticas. De difícil tratamento, o bacilo é reconhecido na literatura como resistente inclusive aos medicamentos utilizados na terapêutica da tuberculose. O objetivo deste trabalho foi pesquisar extratos vegetais do Cerrado brasileiro com atividade contra M. fortuitum, empregando a técnica do Microplate Alamar Blue Assay (MABA) como método analítico. Dos 26 extratos testados frente ao M. fortuitum, o extrato apolar de Quassia amara (extrato diclorometanico) foi o que apresentou melhor resultado com valor de CIM de 62,5µg/mL seguidos pelos extratos apolares de Syngonanthus macrolepsis, Davilla elliptica, Turnera ulmifolia com CIM de 125µg/mL. Para as mesmas plantas analisadas, utilizando-se agentes extratores polares (etanol e metanol), foram verificados CIM superiores a 500µg/mL. Os valores foram semelhantes aos de extratos de outras plantas analisadas sendo considerados não promissores. Palavras-chave: M. fortuitum, plantas do Cerrado, fitoterápicos, Microplate Alamar Blue Assay (MABA).
dc.languagepor
dc.relationRevista de Ciências Farmacêuticas Básica e Aplicada
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCerrado plants
dc.subjectM. fortuitum
dc.subjectMicroplate Alamar Blue Assay (MABA)
dc.subjectPhytotherapy
dc.subjectAnanas ananassoides extract
dc.subjectByrsonima cinera extract
dc.subjectCerrado extract
dc.subjectCissus suscicaulis extract
dc.subjectDavilla elliptica extract
dc.subjectEriocaulon ligulatum extract
dc.subjectLeiothrix flavescens extract
dc.subjectMaoriri pusa extract
dc.subjectplant extract
dc.subjectQuassia amara extract
dc.subjectSolanum ceruum extract
dc.subjectStrychnos pseudoquina extract
dc.subjectSyngonanthus artrothichus extract
dc.subjectSyngonanthus bissulcatus extract
dc.subjectSyngonanthus macrolepsis extract
dc.subjectSyngonanthus xerantemoides extract
dc.subjectTurnera ulmifolia extract
dc.subjectassay
dc.subjectdrug effect
dc.subjectMycobacterium fortuitum
dc.subjectphytotherapy
dc.subjectscrub
dc.titlePlantas do cerrado brasileiro com atividade contra Mycobacterium fortuitum
dc.typeOtro


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