Acute Trypanosoma cruzi experimental infection induced renal ischemic/reperfusion lesion in mice

dc.creatorOliveira, Gabriel Melo de
dc.creatorSilva, Tshaca Mahatma da
dc.creatorBatista, Wanderson Silva
dc.creatorFranco, Marcello
dc.creatorSchor, Nestor
dc.date2019-01-17T14:20:05Z
dc.date2019-01-17T14:20:05Z
dc.date2009
dc.date.accessioned2023-09-27T00:15:20Z
dc.date.available2023-09-27T00:15:20Z
dc.identifierOLIVEIRA, Gabriel Melo de; et al. Acute Trypanosoma cruzi experimental infection induced renal ischemic/reperfusion lesion in mice. Parasitol Res., v.106, p.111–120, 2009.
dc.identifier0932-0113
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31111
dc.identifier10.1007/s00436-009-1637-0
dc.identifier1432-1955
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8899005
dc.descriptionExperimental acute infection with Trypanosoma cruzi in mice promotes an intense myocarditis and other systemic changes. However, the network of pathophysiological disorders and renal injury caused by the infection has not been elucidated. Our previous results with a murine model observed a discrete acute myocarditis and high mortality with significant inflammatory kidney injury with T. cruzi infection. The aim of this study was to investigate the mechanisms of kidney injury caused by the parasite in mice during the experimental acute phase. Results employing BALB/c mice infected with T. cruzi of Y strain showed renal injury on the 6th day postinfection (dpi) caused by a transitory decrease of renal blood flow. Acute kidney injury (AKI) was also observed similar to the model of ischemia/reperfusion lesion in these infected mice. The injury was not related to the presence (or multiplication) of parasites. Only rare nests were microscopically detected, and the presence of scattered parasites in renal parenchyma was seen on the 15th dpi. Thus, it was observed that during the acute phase of the disease, AKI in infected mice is linked to early cardiovascular effects, including heart failure, caused by striking inflammatory lesions in the myocardium, which lead to the high mortality rate of animals.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag (Germany)
dc.rightsrestricted access
dc.subjectTrypanosoma cruzi
dc.subjectInfecção experimental aguda
dc.subjectLesão isquêmica
dc.subjectReperfusão renal
dc.subjectCamundongos
dc.subjectTrypanosoma cruzi
dc.subjectRenal ischemic/reperfusion lesion
dc.subjectAcute experimental infection
dc.subjectMice
dc.titleAcute Trypanosoma cruzi experimental infection induced renal ischemic/reperfusion lesion in mice
dc.typeArticle


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