Article
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease
Registro en:
CURVO, Eduardo O. V. et al. Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 4, p. 1-8, 2018.
0074-0276
10.1590/0074-02760170440
1678-8060
Autor
Curvo, Eduardo O. V.
Ferreira, Roberto R.
Madeira, Fabiana S.
Alves, Gabriel F.
Chambela, Mayara C.
Mendes, Veronica G.
Sangenis, Luiz Henrique C.
Waghabi, Mariana C.
Saraiva, Roberto M.
Resumen
BACKGROUND: Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function. OBJECTIVES We determined whether TGF-β1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease. METHODS: This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-β1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left
atrial and LV diameters, as well as LV ejection fraction and diastolic function. FINDINGS: TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-β1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction. CONCLUSIONS: TNF is increased, while TGF-β1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-β1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.