Article
Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study
Registro en:
GANDHI, Monica. et al. Age, Baseline Kidney Function, and Medication Exposure Are Associated with Declines in Creatinine Clearance on PrEP: An Observational Cohort Study. The lancet HIV, v. 3, n. 11, p. e521–e528, 2016.
10.1016/S2352-3018(16)30153-9
Autor
Gandhi, Monica
Glidden, David V.
Mayer, Kenneth
Schechter, Mauro
Buchbinder, Susan
Grinsztejn, Beatriz
Hosek, Sybil
Casapia, Martin
Guanira, Juan
Bekker, Linda-Gail
Louie, Alexander
Horng, Howard
Benet, Leslie Z.
Liu, Albert
Grant, Robert M.
Resumen
As pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine for the prevention of HIV infection is rolled out internationally, strategies to maintain effectiveness and to minimise adverse effects merit consideration. In this study, we aimed to assess reductions in renal function and predictors of renal toxicity in a large open-label study of PrEP. 2018-12-03