Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi

dc.creatorSoares, Milena Botelho Pereira
dc.creatorGonçalves, Renata
dc.creatorPyrrho, Alexandre dos Santos
dc.creatorCosta, Deise de Andrade
dc.creatorPaiva, Claudia Neto
dc.creatorGattass, Cerli Rocha
dc.date2015-04-08T16:51:46Z
dc.date2015-04-08T16:51:46Z
dc.date2003
dc.date.accessioned2023-09-27T00:09:50Z
dc.date.available2023-09-27T00:09:50Z
dc.identifierSOARES, M. B. P. et al. Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi. Anais da Academia Brasileira de Ciências, v. 75, n. 2, p. 167-172, 2003.
dc.identifier0001-3765
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9931
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898074
dc.descriptionWe have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-gamma and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant differences were found regarding IL-4 production by splenocytes from CL-14-inoculated or control groups after challenge with CL-strain. Our results show that protection against acute T. cruzi infection induced by CL-14 inoculation correlates with a balanced T1/T2 cytokine production, a profile likely to be beneficial for the host.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAcademia Brasileira de Ciências
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectProtection
dc.subjectCytokines
dc.subjectHumoral response
dc.subjectAnticorpos Antiprotozoários/imunologia
dc.subjectCitocinas/biossíntese
dc.subjectTrypanosoma cruzi/imunologia
dc.subjectAnimais
dc.subjectCitocinas/sangue
dc.subjectImunização
dc.subjectInterferon gama/biossíntese
dc.subjectInterferon gama/sangue
dc.subjectInterleucina-2/biossíntese
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.titleBalanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi
dc.typeArticle


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