Preprint
Long non-coding RNA polymorphisms influence susceptibility to endemic pemphigus foliaceus
Registro en:
ALVES, Sara Cristina Lobo et al. Long non-coding RNA polymorphisms influence susceptibility to endemic pemphigus foliaceus. British Journal of Dermatology, p. 1-23, Jan. 2019.
10.1111/bjd.17640
Autor
Alves, Sara Cristina Lobo
Augusto, Danillo Gardenal
Magalhães, Wagner Carlos Santos
Santos, Eduardo Martin Tarazona
Costa, Maria Fernanda Lima
Barreto, Maurício Lima
Horta, Bernardo Lessa
Almeida, R. C. de
Petzl-Erler, Maria Luiza
Resumen
Barreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. Conselho Nacional de
Desenvolvimento Científico e Tecnológico (CNPq), Fundação Araucária, and Coordenação
de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Pemphigus foliaceus (PF) is an epidermal autoimmune disease, characterized by the presence of autoantibodies against the desmosomal protein desmoglein 1. Genetic and environmental factors contribute to PF, a complex disease that is endemic in Brazil and Colombia and neighbouring countries, and in Tunisia. Long non-coding RNAs (lncRNAs) may participate in gene regulation by interacting with DNA, proteins, and other RNAs. Dysregulation of lncRNAs has recently been recognized as an important co-player in the onset or progression of complex diseases. In addition, single-nucleotide polymorphisms (SNP) located in lncRNA genes have been associated with differential risk to cancer, autoimmunity and infection.