L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum

dc.creatorAlmeida-Paes, Rodrigo
dc.creatorAlmeida-Silva, Fernando
dc.creatorPinto, Gabriela Costa Maia
dc.creatorAlmeida, Marcos de Abreu
dc.creatorMuniz, Mauro de Medeiros
dc.creatorPizzini, Claudia Vera
dc.creatorGerfen, Gary J.
dc.creatorNosanchuk, Joshua Daniel
dc.creatorZancopé-Oliveira, Rosely Maria
dc.date2019-02-19T11:33:42Z
dc.date2019-02-19T11:33:42Z
dc.date2018
dc.date.accessioned2023-09-27T00:08:14Z
dc.date.available2023-09-27T00:08:14Z
dc.identifierALMEIDA-PAES, Rodrigo et al. L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum. Medical Mycology, v. 56, 506–509, 2018.
dc.identifier1369-3786
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31723
dc.identifier10.1093/mmy/myx068
dc.identifier1460-2709
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897796
dc.descriptionMelanization of Histoplasma capsulatum remains poorly described, particularly in regards to the forms of melanin produced. In the present study, 30 clinical and environmental H. capsulatum strains were grown in culture media with or without L-tyrosine under conditions that produced either mycelial or yeast forms. Mycelial cultures were not melanized under the studied conditions. However, all strains cultivated under yeast conditions produced a brownish to black soluble pigment compatible with pyomelanin when grew in presence of L-tyrosine. Sulcotrione inhibited pigment production in yeast cultures, strengthening the hyphothesis that H. capsulatum yeast forms produce pyomelanin. Since pyomelanin is produced by the fungal parasitic form, this pigment may be involved in H. capsulatum virulence.
dc.description2020-01-31
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectHistoplasma capsulatum
dc.subjectL-tyrosine
dc.subjectPyomelanin
dc.titleL-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
dc.typeArticle


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