Article
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response
Registro en:
BITTAR, C. et al. Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response. BMC Infectious Diseases, v. 10, p. 36, 2010
1471-2334
10.1186/1471-2334-10-36
Autor
Bittar, Cíntia
Jardim, Ana Carolina Gomes
Yamasaki, Lilian Hiromi Tomonari Yamasaki
Queiróz, Artur Trancoso Lopo de
Carareto, Claudia Maria Aparecida
Pinho, João Renato Rebello
Mello, Isabel Maria Vicente Guedes de Carvalho
Rahal, Paula
Resumen
Artur Trancoso Lopo de Queiroz “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. FAPESP and CAPES. The quasispecies nature of HCV may have important implications for viral persistence, pathogenicity and resistance to antiviral agents. The variability of one of the viral proteins, NS5A, is believed to be related to the response to IFN therapy, the standard treatment for infection. In this study we analyzed the quasispecies composition of NS5A protein in patients infected with HCV genotype 3a, before IFN therapy.