Article
Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo
Registro en:
SOUZA, Elen M. de et al. Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. Journal of Antimicrobial Chemotherapy, v. 58, p. 610-614, July 2006.
0305-7453
10.1093/jac/dkl259
1460-2091
Autor
Souza, Elen M. de
Oliveira, Gabriel M.
Boykin, David W.
Kumar, Arvind
Hu, Qiyue
Soeiro, Maria Nazaré C.
Resumen
Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. One such compound is furamidine (DB75) and we recently reported that one of its analogues, an N-phenyl analogue (DB569), exhibits higher trypanocidal dose and time-dependent effects against different forms of Trypanosoma cruzi as compared with DB75. Our present aim was to investigate the efficacy of DB569 in a T. cruzi mouse model. 2025-01-01