Preprint
Unveiling the relevance of the redox character of nitroaromatic and nitroheteroaromatic compounds as Q6 potential medicines
Registro en:
XAVIER, Jadriane de Almeida et al. Unveiling the relevance of the redox character of nitroaromatic and nitroheteroaromatic compounds as potential medicines. Current Opinion in Electrochemistry, online xxx 10p, 2021.
Autor
Xavier, Jadriane de Almeida
Silva, Thaissa L.
Santos, Eduardo Caio Torres
Vasconcelos, Camila Calado de
Boane, Anastacio
Santos, Ricardo Alexandre dos
Xavier, Andre Felippe A.
Goulart, Marília O. F
Resumen
This review discusses the state of the art, challenges, and
perspectives in recent applications of nitroaromatics and
nitroheteroaromatics, which are redox-bio-activated drugs or
leads, in Medicinal Chemistry. It deals mainly with the elec trochemical approach toward the electron transfer-based mo lecular mechanisms of drug action, drug design, estimation
and measurement of redox potentials, correlation of physico chemical and pharmacological data, and electrochemical
studies of the main representatives of nitro-containing
prodrugs, along with approaches to combat their toxicity
issues, aiming at a better therapeutic profile. Electrochemical
investigation plays essential roles, being strategic in the design
and discovery of potential medicines. 2023