Article
Update of the global distribution of human gammaherpesvirus 8 genotypes
Registro en:
LOPES, Amanda de Oliveira. Update of the global distribution of human gammaherpesvirus 8 genotypes. Scientific Reports, v. 11, n.7640, 9 p, 2021.
2045-2322
10.1038/s41598-021-87038-9
Autor
Lopes, Amanda de Oliveira
Spitz, Natália
Reis, Christian Robson de Souza
Paula, Vanessa Salete de
Resumen
Human gammaherpesvirus 8 (HHV-8) consists of six major clades (A–F) based on the genetic
sequence of the open reading frame (ORF)-K1. There are a few conficting reports regarding the global
distribution of the diferent HHV-8 genotypes. This study aimed to determine the global distribution
of the diferent HHV-8 genotypes based on phylogenetic analysis of the ORF-K1 coding region using
sequences published in the GenBank during 1997–2020 and construct a phylogenetic tree using the
maximum likelihood algorithm with the GTR+ I +G nucleotide substitution model. A total of 550
sequences from 38 countries/origins were analysed in this study. Genotypes A and C had similar global
distributions and were prevalent in Africa and Europe. Genotype B was prevalent in Africa. Of the rare
genotypes, genotype D was reported in East Asia and Oceania and genotype E in South America, while
genotype F was prevalent in Africa. The highest genotypic diversity was reported in the American
continent, with Brazil housing fve HHV-8 genotypes (A, B, C, E, and F). In this study, we present
update of the global distribution of HHV-8 genotypes, providing a basis for future epidemiological and
evolutionary studies of HHV-8.