An investigation of the clonality of human autoimmune thyroglobulin antibodies and their light chains

dc.creatorNye, Lynn
dc.creatorPontes-de-Carvalho, Lain Carlos
dc.creatorRoitt, I. M
dc.date2017-09-04T13:48:07Z
dc.date2017-09-04T13:48:07Z
dc.date1981
dc.date.accessioned2023-09-27T00:00:44Z
dc.date.available2023-09-27T00:00:44Z
dc.identifierNYE, L.; PNTES-DE-CARVALHO, L. C.; ROITT, I. M. CARVALHOAn investigation of the clonality of human autoimmune thyroglobulin antibodies and their light chains. Clinical an Experimental Immunology, v. 46, p. 161-170, 1981.
dc.identifier0009-9104
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20898
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896520
dc.descriptionPontes-de-Carvalho, Lain Carlos “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionConselho Nacional de Desenvolvimento Cientifico e Tecnológico.
dc.descriptionThyroglobulin antibodies in the sera from 31 patients with a variety of disorders were studied by isoelectric focusing. Only one gave a spectrotype indicative of a monoclonal response, the other 30 giving spectrotypes characteristic of polyclonal responses. There was evidence of clonal dominance in some of the sera and each gave a different spectrotype. Light chains were prepared from five thyroglobulin antibodies purified by affinity chromatography. There was no restriction in the spectrotypes when compared with light chains prepared from normal immunoglobulin.
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsopen access
dc.subjectTireoglobulina
dc.subjectAnticorpos
dc.subjectCromatografia de Afinidade
dc.subjectImunoglobulina
dc.subjectThyroglobulin
dc.subjectAntibodies
dc.subjectAffinity chromatography
dc.subjectImmunoglobulin
dc.titleAn investigation of the clonality of human autoimmune thyroglobulin antibodies and their light chains
dc.typeArticle


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