| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Salgado, Hérida Regina Nunes | |
| dc.creator | De Menezes, Manoel | |
| dc.creator | Storti, Madge Patrícia Betto | |
| dc.date | 2014-05-27T11:21:18Z | |
| dc.date | 2016-10-25T18:20:39Z | |
| dc.date | 2014-05-27T11:21:18Z | |
| dc.date | 2016-10-25T18:20:39Z | |
| dc.date | 2005-04-01 | |
| dc.date.accessioned | 2017-04-06T01:12:56Z | |
| dc.date.available | 2017-04-06T01:12:56Z | |
| dc.identifier | Acta Farmaceutica Bonaerense, v. 24, n. 2, p. 246-249, 2005. | |
| dc.identifier | 0326-2383 | |
| dc.identifier | http://hdl.handle.net/11449/68197 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/68197 | |
| dc.identifier | 2-s2.0-23044492305 | |
| dc.identifier | http://www.latamjpharm.org/trabajos/24/2/LAJOP_24_2_3_1_48439399MF.pdf | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/889565 | |
| dc.description | Flutamide is a potent antiandrogen used for the treatment of prostatic cancer. A simple, sensitive and accurate high-performance liquid Chromatographic (HPLC) method is presented for quantitative determination of flutamide in tablets, using a reversed-phase technique and UV detection at 240 nm. The isocratic elution was used to quantify the analyte. The samples were chromatographed on Luna-C18 column and the mobile phase was 0.05 M phosphate buffer pH 4.0 - acetonitrile (50:50, v/v). The method was linear between 2.9 - 11.6 mg L -1. Over the tested concentration range the intra-day relative standard deviation for replicate analysis in tablets ranged from 0.44 to 0.78%. It was also found that the excipients in the commercial tablets did not interfere with the method. | |
| dc.language | eng | |
| dc.relation | Acta Farmaceutica Bonaerense | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Analysis in tablets | |
| dc.subject | Flutamide | |
| dc.subject | High-performance liquid chromatography (HPLC) | |
| dc.subject | Pharmaceutical analysis | |
| dc.subject | acetonitrile | |
| dc.subject | flutamide | |
| dc.subject | drug determination | |
| dc.subject | high performance liquid chromatography | |
| dc.subject | prostate cancer | |
| dc.subject | reversed phase high performance liquid chromatography | |
| dc.subject | tablet | |
| dc.title | Determination of flutamide in tablets by high-performance liquid chromatography | |
| dc.type | Otro | |
