Article
Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques
Registro en:
BONALDO, Myrna C. et al. Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8 T-Cell Responses in Rhesus Macaques. Journal of Virology, v.84, n.8, p.3699-3706, Apr. 2010.
0022-538X
10.1128/JVI.02255-09
1098-5514
Autor
Bonaldo, Myrna C.
Martins, Mauricio A.
Rudersdorf, Richard
Mudd, Philip A.
Sacha, Jonah B.
Piaskowski, Shari M.
Neves, Patrícia C. Costa
Santana, Marlon G. Veloso de
Vojnov, Lara
Capuano, Saverio
Rakasz, Eva G.
Wilson, Nancy A.
Fulkerson, John
Sadoff, Jerald C.
Watkins, David I.
Galler, Ricardo
Resumen
Here we describe a novel vaccine vector for expressing human immunodeficiency virus (HIV) antigens. We show that recombinant attenuated yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 Gag sequences can be used as a vector to generate SIV-specific CD8(+) T-cell responses in the rhesus macaque. Priming with recombinant BCG expressing SIV antigens increased the frequency of these SIV-specific CD8(+) T-cell responses after recombinant YF17D boosting. These recombinant YF17D-induced SIV-specific CD8(+) T cells secreted several cytokines, were largely effector memory T cells, and suppressed viral replication in CD4(+) T cells.