Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining

dc.creatorPereira Filho, José do Egypto
dc.creatorAmorim, Daniele Meneses de
dc.creatorSweet, Glória Maria Maranhão
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorAthanazio, Paulo Roberto Fontes
dc.creatorAthanazio, Daniel Abensur
dc.date2014-06-09T17:10:16Z
dc.date2014-06-09T17:10:16Z
dc.date2012
dc.date.accessioned2023-09-26T23:49:26Z
dc.date.available2023-09-26T23:49:26Z
dc.identifierPEREIRA FILHO, J. do E. et al. Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining. Annals of Diagnostic Pathology, v. 16, p. 397–401, 2012.
dc.identifier1092-9134
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7806
dc.identifier10.1016/j.anndiagpath.2011.03.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894601
dc.descriptionRenal angiomyolipoma (AML) may present as rare variants such as epithelioid and AML with epithelial cysts posing difficulties for the diagnosis to the surgical pathologist. We report a case of a 46-year-old male patient presenting a 5-cm solid tumor in the lower pole of the left kidney, with cystic changes at cut surface. The tumor exhibited 95% of epithelioid cells with atypical nuclei. A small focus of typical AML was observed. The immunoprofile of tumor cells was classical of AML including expression of melanocytic markers such as HMB45 and Melan A. We report the immunohistochemical study of the cystic component in an epithelioid AML. In contrast to the immunoreactivity reported in typical AML, the present case shows obvious expression of melanocytic markers in the cystic epithelial lining. This is strong evidence that these cysts are neoplastic and derived from AML, rather than entrapped native collecting duct epithelium. © 2012 Elsevier Inc. All rights reserved.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Inc
dc.rightsopen access
dc.subjectAngiomyolipoma;
dc.subjectKidney
dc.subjectPerivascular epithelioid cell neoplasms
dc.subjectImmunohistochemistry
dc.subjectKidney neoplasms
dc.titleRenal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining
dc.typeArticle


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