Article
Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case
Registro en:
BOTTECCHIA, Marcelle; et al. Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. Journal of Gastroenterology and Hepatology, v. 23, p. 67–72, 2008.
0815-9319
10.1111/j.1440-1746.2007.05238.x
1440-1746
Autor
Bottecchia, Marcelle
Ikuta, Nilo
Niel, Christian
Araujo, Natalia M.
O, Kycia M. R.
Gomes, Selma A.
Resumen
Resistance to lamivudine therapy of chronic hepatitis B virus (HBV) infection occurs by mutation in the YMDD motif of the reverse transcriptase (rt) domain (rtM204V/I) of the virus polymerase, and is usually accompanied by rtL180M mutation. Here we investigated virological factors associated with hepatic failure in a 58-year-old male, chronically HBV-infected patient who died after 33 months of lamivudine therapy. 2030-01-01