Comparative analysis of noncoding sequences of orthologous bovine and human gene pairs

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMiziara, Melissa Nunes
dc.creatorRiggs, Penny K.
dc.creatorAmaral, M. Elisabete J.
dc.date2014-05-27T11:21:13Z
dc.date2016-10-25T18:20:13Z
dc.date2014-05-27T11:21:13Z
dc.date2016-10-25T18:20:13Z
dc.date2004-12-01
dc.date.accessioned2017-04-06T01:11:30Z
dc.date.available2017-04-06T01:11:30Z
dc.identifierGenetics and Molecular Research, v. 3, n. 4, p. 465-473, 2004.
dc.identifier1676-5680
dc.identifierhttp://hdl.handle.net/11449/68026
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68026
dc.identifier2-s2.0-14644423328.pdf
dc.identifier2-s2.0-14644423328
dc.identifierhttp://www.geneticsmr.com//year2004/vol3-4/pdf/icob0002.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889408
dc.descriptionGenomic sequence comparison across species has enabled the elucidation of important coding and regulatory sequences encoded within DNA. Of particular interest are the noncoding regulatory sequences, which influence gene transcriptional and posttranscriptional processes. A phylogenetic footprinting strategy was employed to identify noncoding conservation patterns of 39 human and bovine orthologous genes. Seventy-three conserved noncoding sequences were identified that shared greater than 70% identity over at least 100 bp. Thirteen of these conserved sequences were also identified in the mouse genome. Evolutionary conservation of noncoding sequences across diverse species may have functional significance, and these conserved sequences may be good candidates for regulatory elements.
dc.languageeng
dc.relationGenetics and Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBovine
dc.subjectComparative analysis
dc.subjectDNA sequences
dc.subjectGenes
dc.subjectOrthologous
dc.subjectcomparative study
dc.subjectconference paper
dc.subjectDNA determination
dc.subjectDNA sequence
dc.subjectgene identification
dc.subjectgene sequence
dc.subjectgenetic transcription
dc.subjectgenome
dc.subjectmouse strain
dc.subjectnucleotide sequence
dc.subjectstatistical significance
dc.subjectunindexed sequence
dc.subject3' Untranslated Regions
dc.subject5' Untranslated Regions
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectCattle
dc.subjectConserved Sequence
dc.subjectEvolution, Molecular
dc.subjectHumans
dc.subjectMice
dc.subjectMolecular Sequence Data
dc.subjectSequence Alignment
dc.subjectSequence Analysis, DNA
dc.subjectBovinae
dc.titleComparative analysis of noncoding sequences of orthologous bovine and human gene pairs
dc.typeOtro


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