Sustained Virologic Suppression Reduces HIV-1 DNA Proviral Levels and HIV Antibodies in Perinatally HIV-Infected Children Followed from Birth

dc.creatorFuller, Trevon
dc.creatorKein, Tara
dc.creatorCortado, Ruth
dc.creatorTeixeira, Maria de Lourdes Benamor
dc.creatorGouvêa, Maria Isabel Fragoso da Silveira
dc.creatorMoreira, Christianne
dc.creatorCruz, Maria Leticia Santos
dc.creatorPilotto, José Henrique
dc.creatorGomes, Ivete
dc.creatorSantos, Breno
dc.creatorRocha, Tauí
dc.creatorSony, Priya R.
dc.creatorJoão, Esau
dc.creatorShin-Sim, Myung
dc.creatorBryson, Yvonne
dc.creatorNielsen-Saines, Karin
dc.date2022-11-25T19:00:57Z
dc.date2022-11-25T19:00:57Z
dc.date2022
dc.date.accessioned2023-09-26T23:46:05Z
dc.date.available2023-09-26T23:46:05Z
dc.identifierFULLER, Trevon et al. Sustained Virologic Suppression Reduces HIV-1 DNA Proviral Levels and HIV Antibodies in Perinatally HIV-Infected Children Followed from Birth. Viruses, v. 14, 2350, p. 1-13, Oct. 2022.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55805
dc.identifier10.3390/v14112350
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893995
dc.descriptionThe extent to which perinatally HIV-infected children, following cART initiation, develop a low proviral reservoir burden over time, as measured by HIV DNA droplet-digital polymerase chain reaction (ddPCR) and the effect on HIV antibody is not well characterized. We measured proviral HIV DNA and plasma RNA virus load (VL) in 37 perinatally HIV-infected children at 6 months of age who initiated stable cART. At 6–11 years of age, HIV proviral DNA, HIV VL (RNA), and HIV antibody by Western Blot (WB) were assessed. CART was initiated before 6 months of age in 13 children and after 6 months in 24. At school age, the HIV DNA levels did not differ by the timing of cART, and the HIV DNA levels were lower in children with negative/indeterminate WB (p = 0.0256). Children with undetectable HIV RNA VL > 50% of the time since cART initiation had lower median DNA VL than children with undetectable VL < 50% of the time (p = 0.07). Long-term viral suppression in perinatally HIV-infected children is associated with a decrease in HIV antibodies and reduced HIV reservoirs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectTratamento precoce do HIV
dc.subjectCarga do reservatório viral
dc.subjectPCR digital de gota de DNA de HIV
dc.subjectCinética da carga viral
dc.subjectInfecção perinatal por HIV
dc.subjectEarly HIV treatment
dc.subjectViral reservoir burden
dc.subjectHIV DNA droplet digital PCR
dc.subjectViral load kinetics
dc.subjectPerinatal HIV infection
dc.titleSustained Virologic Suppression Reduces HIV-1 DNA Proviral Levels and HIV Antibodies in Perinatally HIV-Infected Children Followed from Birth
dc.typeArticle


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