Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes

dc.creatorPontes-de-Carvalho, Lain Carlos
dc.creatorVieira, Joseli Lannes
dc.creatorSavino, Wilson
dc.date2012-12-18T21:21:47Z
dc.date2012-12-18T21:21:47Z
dc.date1987
dc.date.accessioned2023-09-26T23:45:01Z
dc.date.available2023-09-26T23:45:01Z
dc.identifierPONTES-DE-CARVALHO, Lain Carlos; VIEIRA, Joseli Lannes; SAVINO, Wilson. Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes. Memórias do Instituto Oswaldo Cruz, v. 82, supl.2, p. 111-115, 1987.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6029
dc.identifier10.1590/S0074-02761987000600017
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893816
dc.descriptionCNPq
dc.descriptionUNDP/World Bank WHO-TDR
dc.descriptionDespite the existence of erythrocyte-autoreactive B cells in normal animals, erythrocyte-autoantibodies could not be detected during polyclonal B-cell activation (PBA) both in patients with visceral leishmaniasis and in bacterial lipopolysacharide (LPS) - injected mice. The failure to detect these autoantibodies in mice with PBA di not seem to be due to suppressor-cell activity, since (1) transfer of spleen cells from LPS-treated mice to naive recipients did not affect the erythrocyte-autoantibody response elicited by subsequent injections of rat erythrocytes and (2) low doses of X-radiation did no lead to erythrocyte-autoantibody detection in LPS-treated mice. The possibility that the detection of erytrocyte-autoantibodies could be affected by autoantibodies with idiotopes mimicring erythrocyte epitopes, the synthesis of which would also be triggerred in PBA, is discussed. Indirect evidence for the existence in normal animal of an expanded lymphocyte population with DNP-binding. Ia-mimicring antigen receptors is presented.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.rightsopen access
dc.subjectCélulas B
dc.subjectAutoanticorpos
dc.subjectRepertório
dc.subjectAnimais
dc.subjectCamundongos
dc.subjectB cell
dc.subjectAutoantibodies
dc.subjectRepertoire
dc.subjectAnimals
dc.subjectMice
dc.titleRestriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
dc.typeArticle


Este ítem pertenece a la siguiente institución