Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

dc.creatorSouza, Thiara Manuele Alves de
dc.creatorSantos, Caroline Fernandes
dc.creatorOliveira, Jéssica Araújo da Paixão de
dc.creatorTomé, Larissa Cristina Teixeira
dc.creatorFiestas-Solórzano, Victor Edgar
dc.creatorNunes, Priscila Conrado Guerra
dc.creatorGuimarães, Gabriel Macedo Costa
dc.creatorSánchez-Arcila, Juan Camilo
dc.creatorPaiva, Iury Amâncio
dc.creatorSouza, Luís Jose de
dc.creatorDamasco, Paulo Vieira
dc.creatorFrutuoso, Válber da Silva
dc.creatorHeringer, Manoela
dc.creatorPinto, Luzia Maria de Oliveira
dc.creatorPinheiro, Roberta Olmo
dc.creatorSantos, Flavia Barreto dos
dc.creatorAzevedo, Elzinandes Leal de
dc.date2022-08-14T17:21:34Z
dc.date2022-08-14T17:21:34Z
dc.date2022
dc.date.accessioned2023-09-26T23:43:09Z
dc.date.available2023-09-26T23:43:09Z
dc.identifierSOUZA, Thiara Manuele Alves de et al. Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection. Pathogens, v. 11, 444, p. 1 - 21, Apr. 2022.
dc.identifier2076-0817
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54631
dc.identifier10.3390/pathogens11040444
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893500
dc.descriptionChikungunya virus (CHIKV) infection causes intense cytokine/chemokine inflammatory responses and debilitating joint pain. Indoleamine2,3–dioxygenase 1 (IDO-1) is an enzyme that initiates the tryptophan degradation that is important in initial host innate immune defense against infectious pathogens. Besides that, IDO-1 activation acts as a regulatory mechanism to prevent overactive host immune responses. In this study, we evaluated IDO-1 activity and cytokine/chemokine patterns in CHIKV patients. Higher IDO-1 (Kyn/Trp ratio) activation was observed during the early acute phase of CHIKV infection and declined in the chronic phase. Importantly, increased concentrations of Tumor Necrosis Factor- (TNF- ), Interleukin-6 (IL-6), Interferon (IFN- ), C-C motif chemokine ligand 2/Monocyte Chemoattractant Protein-1 (CCL2/MCP-1) and C-X-C motif chemokine ligand 10/Interferon Protein-10 (CXCL10/IP-10) were found in the acute phase of infection, while C-C motif chemokine ligand 4/Macrophage Inflammatory Protein 1 (CCL4/MIP-1 ) was found at increased concentrations in the chronic phase. Likewise, CHIKV patients with arthritis had significantly higher concentrations of CCL4/MIP-1 compared to patients without arthritis. Taken together, these data demonstrated increased IDO-1 activity, possibly exerting both antiviral effects and regulating exacerbated inflammatory responses. CCL4/MIP-1 may have an important role in the persistent inflammation and arthritic symptoms following chikungunya infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectChikungunya
dc.subjectIndoleamina 2,3-dioxigenase 1
dc.subjectCitocinas
dc.subjectQuimiocinas
dc.subjectChikungunya
dc.subjectIndoleamine 2,3-dioxygenase 1
dc.subjectCytokines
dc.subjectChemokines
dc.titleIncreased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection
dc.typeArticle


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