A preliminary report on the effect of laser therapy on the healing of cutaneous surgical wounds as a consequence of an inversely proportional relationship between wavelength and intensity: Histological study in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDo Nascimento, Patrícia Maria
dc.creatorPinheiro, Antonio Luiz B.
dc.creatorSalgado, Miguel Ângelo Castilho
dc.creatorRamalho, Luciana Maria Pedreira
dc.date2014-05-27T11:21:12Z
dc.date2016-10-25T18:20:05Z
dc.date2014-05-27T11:21:12Z
dc.date2016-10-25T18:20:05Z
dc.date2004-12-01
dc.date.accessioned2017-04-06T01:10:59Z
dc.date.available2017-04-06T01:10:59Z
dc.identifierPhotomedicine and Laser Surgery, v. 22, n. 6, p. 513-518, 2004.
dc.identifier1549-5418
dc.identifierhttp://hdl.handle.net/11449/67965
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67965
dc.identifier10.1089/pho.2004.22.513
dc.identifierWOS:000226127600011
dc.identifier2-s2.0-13844316789
dc.identifierhttp://dx.doi.org/10.1089/pho.2004.22.513
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889349
dc.descriptionObjective: The objective of the present investigation was to assess the histological effects of different wavelengths and intensities on the healing process of cutaneous wounds. Background Data: Tissue repair is a dynamic interactive process which involves mediators, cells and extra-cellular matrix. Several reports on the use of laser therapy have shown that the healing process is positively affected when the correct parameters are used. Methods: Eighteen standardized wounds were surgically created on the dorsum of male and female Wistar rats, which were subsequently divided into two experimental groups according to wavelength used λ.670 or λ685 nm) for lasertherapy (LLLT). Each group was divided into three subgroups of three animals according to the intensity of the applied irradiation (2,15, or 25 mW). Twelve animals were used as entreated controls and were not irradiated. The irradiation was carried out during seven consecutive days. The animals were sacrificed eight days after surgery. The specimens were removed, kept in 4% formaldehyde for 24 h, routinely prepared to wax, stained with H&E, and analyzed under light microscopy. Results: For both groups, light microscopy showed a substitution repair process; however, when LLLT was used, a positive biomodulatory effect was detectable, chiefly associated with shorter wavelength and low intensity. Conclusions: The results of the present study indicate that LLLT improved cutaneous wound repair and that the effect is a result of an inversely proportional relationship between wavelength and intensity, with treatment more effective when combining higher intensity with short wavelength or lower intensity with higher wavelength.
dc.languageeng
dc.relationPhotomedicine and Laser Surgery
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanimal
dc.subjectlow level laser therapy
dc.subjectpathology
dc.subjectradiation exposure
dc.subjectrat
dc.subjectskin
dc.subjectWistar rat
dc.subjectwound healing
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthistology
dc.subjectmale
dc.subjectmicroscopy
dc.subjectnonhuman
dc.subjectspectrum
dc.subjectsurgical wound
dc.subjecttissue repair
dc.subjecttreatment outcome
dc.subjectAnimals
dc.subjectLaser Therapy, Low-Level
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSkin
dc.subjectWound Healing
dc.subjectCells
dc.subjectFormaldehyde
dc.subjectHistology
dc.subjectLiving systems studies
dc.subjectMedical problems
dc.subjectOptical microscopy
dc.subjectRepair
dc.subjectSurgery
dc.subjectTissue
dc.subjectBiomodulatory effects
dc.subjectCutaneous wounds
dc.subjectLaser therapy
dc.subjectTissue repair
dc.subjectLaser beam effects
dc.titleA preliminary report on the effect of laser therapy on the healing of cutaneous surgical wounds as a consequence of an inversely proportional relationship between wavelength and intensity: Histological study in rats
dc.typeOtro


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