Article
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia
Registro en:
BRITO, R. DE C. C. M. de et al. The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia. BMC Pulmonary Medicine, v. 16, n. 1, dez. 2016.
1471-2466
10.1186/s12890-016-0324-z
Autor
Brito, Rita de Cássia Coelho Moraes de
Lucena-Silva, Norma
Torres, Leuridan Cavalcante
Luna, Carlos Feitosa
Correia, Jaílson de Barros
Silva, Giselia Alves Pontes da
Resumen
Background: To identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between
serum cytokine profile of children with different pneumonia severity.
Methods: In 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration
of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests,
Pearson correlation and ROC curve for cut-off definition of cytokines.
Results: At admission, IL-6 serum levels were high in mild or severe pneumonia, and was associated to vomiting (P = 0.
019) in both groups; and also to dyspnea (P = 0.012) and white blood cell count (P = 0.045) in patients with severe
pneumonia. IL-10 levels were also high in patients with pneumonia and were associated to lymphocytosis (P = 0.025).
The ROC curve of the IL-6:IL-10 serum levels ratio discriminated severe pneumonia cases at admission, and persistence
of infection in the third day of antibiotic therapy, with positive predictive values of 93% and 89%, respectively.
Conclusions: The balance between IL-6 and IL-10 serum levels showed to be a more discriminative marker for severity
definition and evaluation of recovery in patients with pneumonia.