dc.creator | Leite, Ana Cristina Lima | |
dc.creator | Lima, Renata Souza de | |
dc.creator | Moreira, Diogo Rodrigo Magalhães | |
dc.creator | Cardoso, Marcos Veríssimo de Oliveira | |
dc.creator | Brito, Ana Carolina Gouveia de | |
dc.creator | Santos, Luciene Maria Farias dos | |
dc.creator | Hernandes, Marcelo Zaldini | |
dc.creator | Kiperstok, Alice Costa | |
dc.creator | Lima, Ricardo Santana de | |
dc.creator | Soares, Milena Botelho Pereira | |
dc.date | 2015-04-15T17:09:01Z | |
dc.date | 2015-04-15T17:09:01Z | |
dc.date | 2006 | |
dc.date.accessioned | 2023-09-26T23:40:09Z | |
dc.date.available | 2023-09-26T23:40:09Z | |
dc.identifier | LEITE, Ana Cristina Lima et al. Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry, v. 14, n. 11, p. 3749-3757, 2006. | |
dc.identifier | 0968-0896 | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/10007 | |
dc.identifier | 10.1016/j.bmc.2006.01.034 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8892980 | |
dc.description | A novel series of thiosemicarbazone and aminoacyl-thiazolidones derivatives were synthesized. Their structure suggests that these compounds could have anti-Trypanosoma cruzi activity. Biological evaluation indicates that some of these compounds are able to inhibit the growth of T. cruzi in concentrations non-cytotoxic to mammalian cells. Docking studies were carried out in order to investigate the binding pattern of these compounds for the T. cruzi cruzain (TCC) protein, and these showed a significant correlation with experimental data. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.rights | open access | |
dc.subject | Semicarbazidas | |
dc.subject | Tiazóis | |
dc.subject | Tiossemicarbazida | |
dc.subject | Trypanosoma cruzi/efeitos de drogas | |
dc.subject | Animais | |
dc.subject | Ligações de Hidrogênio | |
dc.subject | Técnicas In Vitro | |
dc.subject | Espectroscopia de Ressonância Magnética/métodos | |
dc.subject | Camundongos | |
dc.subject | Camundongos Endogâmicos BALB C | |
dc.subject | Modelos Moleculares | |
dc.subject | Estrutura Molecular | |
dc.subject | Testes de Sensibilidade Parasitária | |
dc.subject | Semicarbazidas/síntese química | |
dc.subject | Sensibilidade e Especificidade | |
dc.subject | Relação Estrutura-Atividade | |
dc.subject | Tiazóis/síntese química | |
dc.subject | Tiossemicarbazida/síntese química | |
dc.title | Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi | |
dc.type | Article | |