Article
Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi
Registro en:
LEITE, Ana Cristina Lima et al. Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry, v. 14, n. 11, p. 3749-3757, 2006.
0968-0896
10.1016/j.bmc.2006.01.034
Autor
Leite, Ana Cristina Lima
Lima, Renata Souza de
Moreira, Diogo Rodrigo Magalhães
Cardoso, Marcos Veríssimo de Oliveira
Brito, Ana Carolina Gouveia de
Santos, Luciene Maria Farias dos
Hernandes, Marcelo Zaldini
Kiperstok, Alice Costa
Lima, Ricardo Santana de
Soares, Milena Botelho Pereira
Resumen
A novel series of thiosemicarbazone and aminoacyl-thiazolidones derivatives were synthesized. Their structure suggests that these compounds could have anti-Trypanosoma cruzi activity. Biological evaluation indicates that some of these compounds are able to inhibit the growth of T. cruzi in concentrations non-cytotoxic to mammalian cells. Docking studies were carried out in order to investigate the binding pattern of these compounds for the T. cruzi cruzain (TCC) protein, and these showed a significant correlation with experimental data.