Comparison of commercial methods and the CLSI broth microdilution to determine the antifungal susceptibility of Candida parapsilosis complex bloodstream isolates from three health institutions in Rio de Janeiro, Brazil

dc.creatorFigueiredo-Carvalho, Maria Helena G.
dc.creatorBarbedo, Leonardo S.
dc.creatorOliveira, Manoel M. E.
dc.creatorBrito-Santos, Fábio
dc.creatorAlmeida-Paes, Rodrigo
dc.creatorZancopé-Oliveira, Rosely M.
dc.date2019-06-05T13:21:34Z
dc.date2019-06-05T13:21:34Z
dc.date2014
dc.date.accessioned2023-09-26T23:29:40Z
dc.date.available2023-09-26T23:29:40Z
dc.identifierFIGUEIREDO-CARVALHO, Maria Helena G. et al. Comparison of commercial methods and the CLSI Broth microdilution to determine the antifungal susceptibility of Candida parapsilosis complex bloodstream isolates from three health institutions in Rio de Janeiro, Brazil. Mycopathologia, v. 178, p. 27-35, 2014.
dc.identifier0301-486X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33384
dc.identifier10.1007/s11046-014-9771-3
dc.identifier1573-0832
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891173
dc.descriptionTwo commercial methods, the Etest and Vitek 2, were compared with the Clinical and Laboratory Standards Institute broth microdilution method to determine the susceptibility of Candida parapsilosis complex to amphotericin B, caspofungin, fluconazole, voriconazole, and itraconazole. One-hundred bloodstream isolates of C. parapsilosis complex from three hospitals in Rio de Janeiro city, Brazil, between 1998 and 2006 were analyzed. C. parapsilosis sensu stricto (61 %) was the predominant species, followed by C. orthopsilosis (37 %) and C. metapsilosis (2 %). Most isolates were susceptible to the tested drugs. However, one C. parapsilosis sensu stricto isolate was considered resistant for amphotericin B. The essential agreement was 100 % between the methods, except for itraconazole (96.3 %). The categorical agreement varied for fluconazole and itraconazole by Etest and for amphotericin B and fluconazole by Vitek 2. This study reinforces the suitability of the commercial methods in routine clinical microbiology laboratories for antifungal susceptibility testing.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag
dc.rightsrestricted access
dc.subjectAntifungals
dc.subjectCandida metapsilosis
dc.subjectCandida orthopsilosis
dc.subjectCandida parapsilosis
dc.subjectFungemia
dc.subjectRio de Janeiro
dc.titleComparison of commercial methods and the CLSI broth microdilution to determine the antifungal susceptibility of Candida parapsilosis complex bloodstream isolates from three health institutions in Rio de Janeiro, Brazil
dc.typeArticle


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