Article
Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
Registro en:
BARBOSA, C. G. et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genetics and Molecular Biology, v. 31, n. 1, p. 29-32, 2008.
1415-4757
Autor
Barbosa, Cynara Gomes
Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Gloria Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
Resumen
Methylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia
in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism
method (PCR-RFLP) to investigateMTHFR C677T and A1298C polymorphism frequencies in 67 patients with
chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently
healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for
A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken
together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or
AML-M3