Article
Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region
Registro en:
GOUVÊA, M. S. G. et al. Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region. Journal of General Virology, v. 90, p. 2638–2643, 2009.
0022-1317
10.1099/vir.0.013615-0
Autor
Gouvêa, Michele Soares Gomes
Soares, Manoel do Carmo Pereira
Bensabath, Gilberta
Mello, Isabel Maria Vicente Guedes de Carvalho
Brito, Elisabete Maria de Figueiredo
Souza, O S C
Queiroz, Artur Trancoso Lopo de
Carrilho, Flair José
Pinho, João Renato Rebello
Resumen
Queiroz, Artur Trancoso Lopo de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. FAPESP (no. 00/11457-1), Instituto Evandro Chagas/SVS/MS–INCT/CNPq, and Alves de Queiroz Family
Fund for Research. The genotypes of hepatitis B (HBV) and delta (HDV) viruses circulating among fulminant hepatitis cases from the western Amazon Basin of Brazil were characterized in this study. HBV and HDV isolates were obtained from liver samples from 14 patients who developed fulminant hepatitis and died during 1978-1989. HBV DNA and HDV RNA were detected in all samples. Phylogenetic analyses of HDV sequences showed that they all clustered with previously characterized sequences of HDV genotype 3 (HDV-3). HBV genotypes F, A and D were found in 50.0, 28.6 and 21.4 % of cases, respectively. These results confirm the predominance of HDV-3 in South America and its association with the severe form of hepatitis, and the finding of the co-infection of HDV-3 with different genotypes of HBV suggests that the association between HDV-3 and HBV-F is not necessarily causally related to a more severe clinical course of infection.
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Hepatitis E virus infection in patients with clinical diagnosis of viral hepatitis in Colombia [Infección por el virus de la hepatitis E en pacientes con diagnóstico clínico de hepatitis viral en Colombia]
Peláez D.; Hoyos M.C.; Rendón J.C.; Mantilla C.; Ospina M.C.; Cortés-Mancera F.; Pérez O.L.; Contreras L.; Estepa Y.; Arbeláez M.P.; Navas M.C. (2014)