Article
Cross-immunity experiments between different species or strains of Leishmania in Rhesus Macaques (Macaca Mulatta)
Registro en:
PORROZZI, Renato; et al. Cross-Immunity experiments between different species or strains of Leishmania in Rhesus Macaques (Macaca Mulatta). Am. J. Trop. Med. Hyg., v.71, n.3, p.297–305, 2004.
0002-9637
1476-1645
Autor
Porrozzi, Renato
Teva, Antonio
Amaral, Veronica F.
Costa, Marcos V. Santos da
Grinaldi Jr., Gabriel
Resumen
This study evaluates cross-immunity in rhesus monkeys (Macaca mulatta) previously infected with one
species of Leishmania and have had self-cured disease or were cured by antimony-based therapy upon development of
full-blown disease. We found that a self-healing cutaneous leishmaniasis (CL) following experimental infection with
Leishmania (Leishmania) major induces significant protection for L. (L.) amazonensis and L. (Viannia) guyanensis, and
was dependent on time of re-challenge by L (L.) amazonensis after animals had recovered from primary lesions, but
lacked protection against L. (V.) braziliensis. In contrast, monkeys that recovered from L. (V.) braziliensis CL or L. (L.)
chagasi visceral leishmaniasis following chemotherapeutic intervention were protected by challenge with L. (V.) braziliensis
and L (L.) amazonensis. These findings indicate the relative variability in protection after self-cure or drugcured
experimental leishmaniasis to challenge by heterologous leishmanial parasites. Further studying the immune
response may provide information regarding relevant factors influencing cross-protective immunity. 2030-01-01