| dc.creator | Miyazaki, Yasunari | |
| dc.creator | Abreu, Adriana Vieira de | |
| dc.creator | Harris, Estelle S | |
| dc.creator | Shah, Amrapali M | |
| dc.creator | Weyrich, Andrew S | |
| dc.creator | Faria Neto, Hugo C. Castro | |
| dc.creator | Zimmerman, Guy A | |
| dc.date | 2015-05-27T13:39:51Z | |
| dc.date | 2015-05-27T13:39:51Z | |
| dc.date | 2014 | |
| dc.date.accessioned | 2023-09-26T23:21:26Z | |
| dc.date.available | 2023-09-26T23:21:26Z | |
| dc.identifier | MIYAZAKI, Yasunari et al. Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling. Plos One, v.11, n.9, 25p, 2014. | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/10548 | |
| dc.identifier | 0.1371/journal.pone.0112770 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8889685 | |
| dc.description | Integrin aDb2 is the most recently identified member of the leukocyte, or b2,
subfamily of integrin heterodimers. Its distribution and functions on human
leukocytes have not been clearly defined and are controversial. We examined
these issues and found that aDb2 is prominently expressed by leukocytes in whole
blood from healthy human subjects, including most polymorphonuclear leukocytes
and monocytes. We also found that aDb2 is displayed by leukocytes in the alveoli of
uninjured and inflamed human lungs and by human monocyte-derived
macrophages and dendritic cells, indicating broad myeloid expression. Using
freshly-isolated human monocytes, we found that aDb2 delivers outside-in signals to
pathways that regulate cell spreading and gene expression. Screening expression
analysis followed by validation of candidate transcripts demonstrated that
engagement of aDb2 induces mRNAs encoding inflammatory chemokines and
cytokines and secretion of their protein products. Thus, aDb2 is a major member of
the integrin repertoire of both circulating and tissue myeloid leukocytes in humans.
Its broad expression and capacity for outside-in signaling indicate that it is likely to
have important functions in clinical syndromes of infection, inflammation, and tissue
injury. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Plos One | |
| dc.rights | open access | |
| dc.subject | Tissue Myeloid Leukocytes | |
| dc.subject | Mediates Inflammatory Signaling | |
| dc.subject | Human Circulating | |
| dc.subject | Integrin αDβ2 (CD11d/CD18) | |
| dc.title | Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling | |
| dc.type | Article | |
