Article
Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
Registro en:
SILVA, Marcus Tulius T. et al. Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection. Clinical Infectious Diseases, v. 44, n. 5, p. 689-692, Mar. 2007.
1058-4838
10.1086/510679
1537-6591
Autor
Silva, Marcus Tulius T.
Harab, Ramza Cabral
Leite, Ana Cláudia
Schor, Doris
Araújo, Abelardo
Andrada-Serpa, Maria José
Resumen
We thank Marcos A. M. Scheiner and Beatriz J. Pereira Vaz for the first experiments of proviral load. We thank Prof. William Hall and Dr. Carla Vorsatz for their review of the English in this manuscript. Financial support. Brazilian National Research Council (CNPq), Fundac¸a˜o Oswaldo Cruz, and Brazilian Health Ministry. Potential conflicts of interest. All authors: no conflicts. Recent reports have demonstrated that human T lymphotropic virus type 1 (HTLV-1) is associated with other neurological abnormalities in addition to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been well established that high HTLV-1 proviral loads are associated with the development of HAM/TSP. We now demonstrate, for the first time, to our knowledge, that HTLV-1 proviral loads in patients with other neurological abnormalities are also significantly higher than in asymptomatic HTLV-1 carriers.