Elasmobranchs are particularly vulnerable to environmental contamination, especially pollutants that may bioaccumulate and biomagnify, throughout the trophic web, such as metals. However, Elasmobranch management and conservation plans are challenging, and this group is often neglected regarding ecotoxicological analyses, particularly concerning metal detoxification mechanisms. This article discusses metallothionein (MT) mediated metal detoxification in Elasmobranchs and reflects on the current knowledge gap in this regard.