Article

Quantification of dengue virus type 3 RNA in fatal and non-fatal cases in Brazil, 2002

Registro en:
ARAÚJO, Josélio M. G. de; et al. Quantification of dengue virus type 3 RNA in fatal and non-fatal cases in Brazil, 2002. Transactions of the Royal Society of Tropical Medicine and Hygiene, v.103, p.952—954, 2009.
0035-9203
10.1016/j.trstmh.2009.01.025
1878-3503
Autor
Araújo, Josélio M. G. de
Filippis, Ana Maria Bispo de
Schatzmayr, Hermann G.
Araújo, Eliane S. M. de
Britto, Constança
Cardoso, Maria A.
Camacho, Luiz A. B.
Nogueira, Rita Maria R.
Institución
Resumen
We examined levels of dengue virus type 3 (DENV-3) RNA in association with the type of infection (primary or secondary) in 42 patients with fatal and non-fatal outcomes in Rio de Janeiro, Brazil, 2002. Subjects with fatal outcomes had mean virus titers significantly higher than those who survived (12.5 vs. 7.9 log(10) RNA copies/ml). Because primary infections were confirmed among the fatal cases (52.1%), antibody-dependent enhancement alone did not explain all the cases of severe disease in this study population. These findings suggest that high levels of DENV-3 may have contributed to the severe form of dengue in Rio de Janeiro, 2002.
 
2030-01-01
 
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