Article
A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity
Registro en:
COSTA, Emmanoel Vilaça et al. A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity. Journal of Natural Products, v. 69, p. 292-294, 2006.
0163-3864
10.1021/np050422s
1520-6025
Autor
Costa, Emmanoel Vilaça
Pinheiro, Maria Lúcia B.
Xavier, Clahildek M.
Silva, Jefferson R. A.
Amaral, Ana Cláudia F.
Souza, Afonso D. L.
Barison, Andersson
Campos, Francinete R.
Ferreira, Antonio G.
Machado, Gérzia M. C.
Leon, Leonor L. P.
Resumen
Bioassay-guided fractionation of the bark extract of Annona foetida afforded a new antileishmanial pyrimidine-â-carboline alkaloid, N-hydroxyannomontine (1), together with the previously reported annomontine (2), O-methylmoschatoline (3), and liriodenine (4). The structure of compound 1 was established on the basis of extensive 1D and 2D NMR and MS analyses. This is the third reported pyrimidine-â-carboline-type alkaloid and is particularly important for Annona genus chemotaxonomy. In addition, all compounds exhibit in vitro antileishmanial activity against promastigote forms of Leishmania braziliensis. Compounds 2 and 4 showed better activity than compounds 1 and 3 against L. braziliensis. Compound 2 was not active against L. guyanensis.